Involvement of amlodipine, diazoxide, and glibenclamide in development of morphine tolerance in mice

Omid Khalilzadeh, Mehdi Anvari, Azita Khalilzadeh, Mousa Sahebgharani, Mohammad R. Zarrindast

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, the effects of the calcium channel blocker (amlodipine), potassium channel opener (diazoxide), and potassium channel blocker (glibenclamide) on the development of morphine-induced tolerance in the formalin test was investigated. During development of tolerance to morphine, intraperitoneal (i.p.) administration of different doses of amlodipine (5, 7.5 and 10 mg/kg) or diazoxide (1, 5 and 10 mg/kg) in combination with morphine (20 and 30 mg/kg) increased tolerance in the first and second phase of the test. However, glibenclamide (2.5, 5, and 10 mg/kg) decreased morphine tolerance in the second phase of formalin test. It is concluded that calcium and potassium channel mechanisms may be involved in the morphine tolerance.

Original languageEnglish (US)
Pages (from-to)503-518
Number of pages16
JournalInternational Journal of Neuroscience
Volume118
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

Keywords

  • Amlodipine
  • Diazoxide
  • Formalin test
  • Glibenclamide
  • Mice
  • Morphine
  • Tolerance

ASJC Scopus subject areas

  • Neuroscience(all)

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