Abstract
In this study, the effects of the calcium channel blocker (amlodipine), potassium channel opener (diazoxide), and potassium channel blocker (glibenclamide) on the development of morphine-induced tolerance in the formalin test was investigated. During development of tolerance to morphine, intraperitoneal (i.p.) administration of different doses of amlodipine (5, 7.5 and 10 mg/kg) or diazoxide (1, 5 and 10 mg/kg) in combination with morphine (20 and 30 mg/kg) increased tolerance in the first and second phase of the test. However, glibenclamide (2.5, 5, and 10 mg/kg) decreased morphine tolerance in the second phase of formalin test. It is concluded that calcium and potassium channel mechanisms may be involved in the morphine tolerance.
Original language | English (US) |
---|---|
Pages (from-to) | 503-518 |
Number of pages | 16 |
Journal | International Journal of Neuroscience |
Volume | 118 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2008 |
Externally published | Yes |
Keywords
- Amlodipine
- Diazoxide
- Formalin test
- Glibenclamide
- Mice
- Morphine
- Tolerance
ASJC Scopus subject areas
- General Neuroscience