Invited review: MDP and other muropeptides - Direct and synergistic effects on the immune system

Stephanie Traub, Sonja von Aulock, Thomas Hartung, Corinna Hermann

Research output: Contribution to journalReview article

Abstract

Muropeptides are breakdown products of peptidoglycan (PGN) of Gram-negative and Gram-positive bacteria. They are released during bacterial growth and division, as part of the host response by lysozyme and amidases, or upon antibiotic treatment. After phagocytosis of bacteria or bacterial breakdown products by host immune cells, the muropeptides trigger intracellular signaling cascades, leading to altered gene expression and activation of the immune response. Numerous muropeptides and derivatives have been synthesized chemically to characterize their immunostimulatory effects and adjuvant activity. Muramyl dipeptide, a natural partial structure of PGN, is the minimal structure with adjuvant activity. This review discusses the structure and occurrence of muropeptides and gives a broad overview of their inflammatory and adjuvant activity and the possible involvement of receptors in these responses.

Original languageEnglish (US)
Pages (from-to)69-85
Number of pages17
JournalJournal of Endotoxin Research
Volume12
Issue number2
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

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Keywords

  • Adjuvant activity
  • Immune response
  • Inflammation
  • Muramyl dipeptide
  • Muropeptides

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Molecular Biology
  • Cell Biology
  • Infectious Diseases

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