Invited commentary: Composite outcomes as an attempt to escape from selection bias and related paradoxes

Miguel A. Hernán, Enrique F. Schisterman, Sonia Hernández-Díaz

Research output: Contribution to journalArticle

Abstract

This commentary reviews the recent history of explanations to crossover paradoxes such as the birth weight and gestational age paradoxes, with a special emphasis on the current proposal by Kramer et al. in this issue of the Journal (Am J Epidemiol. 2014;179(3):361-367). We contend that the causal structure of these paradoxes is essentially identical to that of several well-known selection biases. We then consider the pros and cons of using composite outcomes to circumvent these selection biases.

Original languageEnglish (US)
Pages (from-to)368-370
Number of pages3
JournalAmerican Journal of Epidemiology
Volume179
Issue number3
DOIs
StatePublished - Feb 2014
Externally publishedYes

Keywords

  • causal diagrams
  • composite outcomes
  • paradox
  • selection bias

ASJC Scopus subject areas

  • Epidemiology

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