Investigational drugs in development to prevent neuromyelitis optica relapses

Friedemann Paul, Olwen Murphy, Santiago Pardo, Michael Levy

Research output: Contribution to journalReview article

Abstract

Introduction: In the short time since 2014, three pivotal, worldwide studies in neuromyelitis optica spectrum disorders have been launched: eculizumab, SA237 and inebelizumab, each based on a unique mechanism. Areas covered: In this review, we provide a discussion on the trial data available for each drug, a brief description of the trial design, and our expert opinion on the potential benefits and risks. Expert opinion: Eculizumab, a C5 complement inhibitor, may prove useful in the treatment of intractable cases of NMOSD, but physicians must be aware of the known risk of meningococcal infection. SA237, an interleukin-6 receptor blocker, may be effective at reducing relapse risk, and also has the potential to reduce neuropathic pain in NMOSD. Inebelizumab, a B cell depleting agent, has never been tested in NMOSD, but based on extensive evidence of efficacy with B cell depletion using rituximab, inebelizumab is expected to work at least as well.

Original languageEnglish (US)
Pages (from-to)265-271
Number of pages7
JournalExpert Opinion on Investigational Drugs
Volume27
Issue number3
DOIs
StatePublished - Mar 4 2018

Keywords

  • Neuromyelitis optica
  • biomarkers
  • prognosis
  • risk assessment

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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