Investigation of the DAOA/G30 locus in panic disorder

J. Schumacher; R. Abou Jamra; T. Becker; N. Klopp; P. Franke; C. Jacob; P. Sand; J. Fritze; S. Ohlraun; T. G. Schulze; M. Rietschel; T. Illig; P. Propping; S. Cichon; J. Deckert; M. M. Nöthen

doi:10.1038/sj.mp.4001598

Investigation of the DAOA/G30 locus in panic disorder

J. Schumacher, R. Abou Jamra, T. Becker, N. Klopp, P. Franke, C. Jacob, P. Sand, J. Fritze, S. Ohlraun, T. G. Schulze, M. Rietschel, T. Illig, P. Propping, S. Cichon, J. Deckert, M. M. Nöthen

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23 Scopus citations

Abstract

The authors assessed whether genetic variation at the DAOA/G30 locus contributes to panic disorder (PD) and analyzed five SNPs at this locus in 152 patients and 208 controls. In the single-locus analyses, three SNPs were significantly associated with PD. Further support was obtained at the haplotypic level. Given that the authors have previously observed the same alleles and haplotypes to be associated with bipolar affective disorder and schizophrenia, the results suggest that DAOA/G30 contributes to psychiatric disease beyond diagnostic boundaries.

Original language	English (US)
Journal	Molecular Psychiatry
Volume	10
Issue number	5
DOIs	https://doi.org/10.1038/sj.mp.4001598
State	Published - May 2005
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Psychiatry and Mental health

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title = "Investigation of the DAOA/G30 locus in panic disorder",

abstract = "The authors assessed whether genetic variation at the DAOA/G30 locus contributes to panic disorder (PD) and analyzed five SNPs at this locus in 152 patients and 208 controls. In the single-locus analyses, three SNPs were significantly associated with PD. Further support was obtained at the haplotypic level. Given that the authors have previously observed the same alleles and haplotypes to be associated with bipolar affective disorder and schizophrenia, the results suggest that DAOA/G30 contributes to psychiatric disease beyond diagnostic boundaries.",

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AU - Schumacher, J.

AU - Jamra, R. Abou

AU - Becker, T.

AU - Klopp, N.

AU - Franke, P.

AU - Jacob, C.

AU - Sand, P.

AU - Fritze, J.

AU - Ohlraun, S.

AU - Schulze, T. G.

AU - Rietschel, M.

AU - Illig, T.

AU - Propping, P.

AU - Cichon, S.

AU - Deckert, J.

AU - Nöthen, M. M.

PY - 2005/5

Y1 - 2005/5

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AB - The authors assessed whether genetic variation at the DAOA/G30 locus contributes to panic disorder (PD) and analyzed five SNPs at this locus in 152 patients and 208 controls. In the single-locus analyses, three SNPs were significantly associated with PD. Further support was obtained at the haplotypic level. Given that the authors have previously observed the same alleles and haplotypes to be associated with bipolar affective disorder and schizophrenia, the results suggest that DAOA/G30 contributes to psychiatric disease beyond diagnostic boundaries.

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Investigation of the DAOA/G30 locus in panic disorder

Abstract

ASJC Scopus subject areas

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