Investigation of slow molecular dynamics using R-CODEX

Wenbo Li, Ann McDermott

Research output: Contribution to journalArticlepeer-review

Abstract

A solid state NMR experiment is introduced for probing motions on the millisecond time scale, based on dephasing and refocusing 1H- 13C or 1H-15N dipolar couplings. The method is related to the previously described Centerband-Only Detection of Exchange or CODEX experiment. The use of an R-type dipolar recoupling sequence takes advantage of the strong 1H-13C or 1H- 15N dipolar coupling, while suppressing the effect of 1H-1H homonuclear coupling. This approach paves the way to detect both the correlation time and reorientational angle of the dynamics in fully protonated samples. The performance of this pulse sequence is demonstrated using imidazole methyl sulfonate.

Original languageEnglish (US)
Pages (from-to)74-80
Number of pages7
JournalJournal of Magnetic Resonance
Volume222
DOIs
StatePublished - Sep 2012
Externally publishedYes

Keywords

  • CODEX
  • H homonuclear coupling
  • Imidazole
  • Millisecond dynamics
  • R-CODEX
  • R18
  • Reorientation angle
  • Solid state NMR

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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