Investigation of Multisequence Magnetic Resonance Imaging for Detection of Recurrent Tumor After Transurethral Resection for Bladder Cancer

Andrew B. Rosenkrantz, Islamiat O. Ego-Osuala, Victoria Khalef, Fang Ming Deng, Samir S. Taneja, William C. Huang

Research output: Contribution to journalArticle

Abstract

PURPOSE: The aim of this study was to evaluate multisequence magnetic resonance imaging (MRI) in detecting local recurrence after transurethral resection for bladder cancer. METHODS: Thirty-six patients with bladder cancer with previous transurethral resection underwent bladder MRI incorporating T2-weighted imaging, diffusion-weighted imaging, and delayed contrast-enhanced T1-weighted imaging, followed by cystoscopy. Two radiologists (R1 and R2) evaluated examinations for suspicious findings. RESULTS: Forty-seven percent of patients had recurrent tumor at cystoscopy and biopsy. Using multisequence MRI, sensitivity and specificity were 67% and 81% for R1 and 73% and 62% for R2. Both readers missed 1 high-grade pathologic stage T1 recurrent tumor; otherwise, all missed tumors were low-grade pathologic stage Ta lesions. All false positives for R1 and 7 of 9 false positives for R2 were in patients receiving previous bacillus Calmette-Guerin therapy. Furthermore, 40% to 50% of solitary abnormalities and 83% to 100% of multifocal abnormalities were tumor recurrences; 12% to 20% of smooth wall thickening, 50% to 75% of irregular wall thickening, and 88% to 100% of papillary masses were tumor recurrences. CONCLUSIONS: Although multisequence MRI exhibited moderate performance for detecting recurrent tumor, nearly all missed tumors were low grade and noninvasive.

Original languageEnglish (US)
JournalJournal of Computer Assisted Tomography
DOIs
StateAccepted/In press - Jan 12 2016
Externally publishedYes

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Urinary Bladder Neoplasms
Magnetic Resonance Imaging
Neoplasms
Cystoscopy
Recurrence
Mycobacterium bovis
Urinary Bladder
Biopsy
Sensitivity and Specificity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Investigation of Multisequence Magnetic Resonance Imaging for Detection of Recurrent Tumor After Transurethral Resection for Bladder Cancer. / Rosenkrantz, Andrew B.; Ego-Osuala, Islamiat O.; Khalef, Victoria; Deng, Fang Ming; Taneja, Samir S.; Huang, William C.

In: Journal of Computer Assisted Tomography, 12.01.2016.

Research output: Contribution to journalArticle

Rosenkrantz, Andrew B. ; Ego-Osuala, Islamiat O. ; Khalef, Victoria ; Deng, Fang Ming ; Taneja, Samir S. ; Huang, William C. / Investigation of Multisequence Magnetic Resonance Imaging for Detection of Recurrent Tumor After Transurethral Resection for Bladder Cancer. In: Journal of Computer Assisted Tomography. 2016.
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