Sera collected from 975 cancer patients in 10 cities of India were screened for virus-neutralizing and “tumor” (T) antibodies to simian virus 40. All localities of collection were within the known limits of distribution of the rhesus monkey. The overall prevalence of virus-neutralizing antibodies was 5.3%. The protective sera were distributed in all age groups and had low titers of neutralizing antibodies. In analysis of sera from localities where at least one serum was protective, the prevalence of neutralizing antibodies was comparable in all diagnostic categories of cancer except cancer of the urinary bladder, in which 5 of 11 sera were protective. In indirect fluorescent-antibody tests, no T antibodies were demonstrated in any sera, including those from patients with cancer of the bladder.
ASJC Scopus subject areas
- Cancer Research