Abstract
A case-control mortality study was performed at an aircraft engine factory to assess the possible association between exposure to nickel-containing compounds and death from lung cancer. 42 non-salaried male workers who died of lung cancer from 1966 to 1976 were identified from a chronological registry of death certificates that has been maintained by the company's medical department. Each of the decedents was matched with the next 2 non-salaried decedents in the registry who were of the same sex and comparable age (±10 yr), and who died of causes other than cancer. Without knowledge of the workmen's identities or causes of death, 1 of the authors classified the deceased workmen as exposed or non-exposed to nickel compounds during their employment. The proportion of workmen who died of lung cancer and were exposed to nickel (11/42) was found to be equal to the proportion of workmen who died of non-cancerous causes and were exposed to nickel (22/84). This study indicates that workers in an aircraft engine factory who were chronically exposed to low atmospheric concentrations of presumably weakly carcinogenic nickel compounds did not have any apparent increase in the relative risk of mortality from lung cancer prior to treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 190-194 |
| Number of pages | 5 |
| Journal | Annals of Clinical and Laboratory Science |
| Volume | 8 |
| Issue number | 3 |
| State | Published - 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Clinical Biochemistry
Cite this
Investigation of exposure to nickel and lung cancer mortality. Case control study at aircraft engine factory. / Bernacki, E. J.; Parsons, G. E.; Sunderman, F. W.
In: Annals of Clinical and Laboratory Science, Vol. 8, No. 3, 1978, p. 190-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Investigation of exposure to nickel and lung cancer mortality. Case control study at aircraft engine factory
AU - Bernacki, E. J.
AU - Parsons, G. E.
AU - Sunderman, F. W.
PY - 1978
Y1 - 1978
N2 - A case-control mortality study was performed at an aircraft engine factory to assess the possible association between exposure to nickel-containing compounds and death from lung cancer. 42 non-salaried male workers who died of lung cancer from 1966 to 1976 were identified from a chronological registry of death certificates that has been maintained by the company's medical department. Each of the decedents was matched with the next 2 non-salaried decedents in the registry who were of the same sex and comparable age (±10 yr), and who died of causes other than cancer. Without knowledge of the workmen's identities or causes of death, 1 of the authors classified the deceased workmen as exposed or non-exposed to nickel compounds during their employment. The proportion of workmen who died of lung cancer and were exposed to nickel (11/42) was found to be equal to the proportion of workmen who died of non-cancerous causes and were exposed to nickel (22/84). This study indicates that workers in an aircraft engine factory who were chronically exposed to low atmospheric concentrations of presumably weakly carcinogenic nickel compounds did not have any apparent increase in the relative risk of mortality from lung cancer prior to treatment.
AB - A case-control mortality study was performed at an aircraft engine factory to assess the possible association between exposure to nickel-containing compounds and death from lung cancer. 42 non-salaried male workers who died of lung cancer from 1966 to 1976 were identified from a chronological registry of death certificates that has been maintained by the company's medical department. Each of the decedents was matched with the next 2 non-salaried decedents in the registry who were of the same sex and comparable age (±10 yr), and who died of causes other than cancer. Without knowledge of the workmen's identities or causes of death, 1 of the authors classified the deceased workmen as exposed or non-exposed to nickel compounds during their employment. The proportion of workmen who died of lung cancer and were exposed to nickel (11/42) was found to be equal to the proportion of workmen who died of non-cancerous causes and were exposed to nickel (22/84). This study indicates that workers in an aircraft engine factory who were chronically exposed to low atmospheric concentrations of presumably weakly carcinogenic nickel compounds did not have any apparent increase in the relative risk of mortality from lung cancer prior to treatment.
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M3 - Article
VL - 8
SP - 190
EP - 194
JO - Annals of Clinical and Laboratory Science
JF - Annals of Clinical and Laboratory Science
SN - 0091-7370
IS - 3
ER -