Investigation of colon cancers for human papillomavirus genomic sequences by polymerase chain reaction

Keerti V. Shah, Richard W. Daniel, Jonathan W. Simons, Bert Vogelstein

Research output: Contribution to journalArticlepeer-review

Abstract

Two previous studies have reported the presence of human papillomavirus (HPV) genomic sequences in colorectal cancers. We examined DNAs from 50 colorectal tumors for HPV sequences by polymerase chain reaction (PCR), using HPV consensus L1 primers for amplification. The PCR products were screened with a generic HPV probe consisting of amplimers of HPV‐16 and HPV‐18. All tumor DNAs were negative for HPV sequences. These results call into the question the reported association of colorectal cancers with HPVs. © 1992 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalJournal of Surgical Oncology
Volume51
Issue number1
DOIs
StatePublished - Sep 1992

Keywords

  • cancer etiology
  • human papillomaviruses
  • polymerase chain reaction
  • virus‐associated cancers

ASJC Scopus subject areas

  • Surgery
  • Oncology

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