Investigation of colon cancers for human papillomavirus genomic sequences by polymerase chain reaction

K. V. Shah, R. W. Daniel, J. W. Simons, Bert Vogelstein

Research output: Contribution to journalArticle

Abstract

Two previous studies have reported the presence of human papillomavirus (HPV) genomic sequences in colorectal cancers. We examined DNAs from 50 colorectal tumors for HPV sequences by polymerase chain reaction (PCR), using HPV consensus L1 primers for amplification. The PCR products were screened with a generic HPV probe consisting of amplimers of HPV-16 and HPV-18. All tumor DNAs were negative for HPV sequences. These results call into the question the reported association of colorectal cancers with HPVs.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalJournal of Surgical Oncology
Volume51
Issue number1
StatePublished - 1992

Fingerprint

Colonic Neoplasms
Polymerase Chain Reaction
Colorectal Neoplasms
Human papillomavirus 18
Human papillomavirus 16
DNA
Neoplasms

Keywords

  • cancer etiology
  • human papillomaviruses
  • polymerase chain reaction
  • virus-associated cancers

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Investigation of colon cancers for human papillomavirus genomic sequences by polymerase chain reaction. / Shah, K. V.; Daniel, R. W.; Simons, J. W.; Vogelstein, Bert.

In: Journal of Surgical Oncology, Vol. 51, No. 1, 1992, p. 5-7.

Research output: Contribution to journalArticle

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