Investigation of anatomical thalamo-cortical connectivity and fMRI activation in schizophrenia

Stefano Marenco, Jason L. Stein, Antonina A. Savostyanova, Fabio Sambataro, Hao Tan, Aaron L. Goldman, Beth A. Verchinski, Alan S. Barnett, Dwight Dickinson, José A. Apud, Joseph H. Callicott, Andreas Meyer-Lindenberg, Daniel Weinberger

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to examine measures of anatomical connectivity between the thalamus and lateral prefrontal cortex (LPFC) in schizophrenia and to assess their functional implications. We measured thalamocortical connectivity with diffusion tensor imaging (DTI) and probabilistic tractography in 15 patients with schizophrenia and 22 age-and sex-matched controls. The relationship between thalamocortical connectivity and prefrontal cortical blood-oxygenation-level-dependent (BOLD) functional activity as well as behavioral performance during working memory was examined in a subsample of 9 patients and 18 controls. Compared with controls, schizophrenia patients showed reduced total connectivity of the thalamus to only one of six cortical regions, the LPFC. The size of the thalamic region with at least 25% of model fibers reaching the LPFC was also reduced in patients compared with controls. The total thalamocortical connectivity to the LPFC predicted working memory task performance and also correlated with LPFC BOLD activation. Notably, the correlation with BOLD activation was accentuated in patients as compared with controls in the ventral LPFC. These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC.

Original languageEnglish (US)
Pages (from-to)499-507
Number of pages9
JournalNeuropsychopharmacology
Volume37
Issue number2
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Prefrontal Cortex
Schizophrenia
Magnetic Resonance Imaging
Short-Term Memory
Thalamus
Diffusion Tensor Imaging
Task Performance and Analysis

Keywords

  • diffusion tensor imaging (DTI)
  • medio-dorsal nucleus
  • prefrontal cortex
  • probabilistic tractography
  • reproducibility
  • working memory

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Investigation of anatomical thalamo-cortical connectivity and fMRI activation in schizophrenia. / Marenco, Stefano; Stein, Jason L.; Savostyanova, Antonina A.; Sambataro, Fabio; Tan, Hao; Goldman, Aaron L.; Verchinski, Beth A.; Barnett, Alan S.; Dickinson, Dwight; Apud, José A.; Callicott, Joseph H.; Meyer-Lindenberg, Andreas; Weinberger, Daniel.

In: Neuropsychopharmacology, Vol. 37, No. 2, 01.2012, p. 499-507.

Research output: Contribution to journalArticle

Marenco, S, Stein, JL, Savostyanova, AA, Sambataro, F, Tan, H, Goldman, AL, Verchinski, BA, Barnett, AS, Dickinson, D, Apud, JA, Callicott, JH, Meyer-Lindenberg, A & Weinberger, D 2012, 'Investigation of anatomical thalamo-cortical connectivity and fMRI activation in schizophrenia', Neuropsychopharmacology, vol. 37, no. 2, pp. 499-507. https://doi.org/10.1038/npp.2011.215
Marenco, Stefano ; Stein, Jason L. ; Savostyanova, Antonina A. ; Sambataro, Fabio ; Tan, Hao ; Goldman, Aaron L. ; Verchinski, Beth A. ; Barnett, Alan S. ; Dickinson, Dwight ; Apud, José A. ; Callicott, Joseph H. ; Meyer-Lindenberg, Andreas ; Weinberger, Daniel. / Investigation of anatomical thalamo-cortical connectivity and fMRI activation in schizophrenia. In: Neuropsychopharmacology. 2012 ; Vol. 37, No. 2. pp. 499-507.
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