TY - JOUR
T1 - Investigating the effects of metabolic dysregulation on hair follicles
T2 - A comparison of HIV-infected women with and without central lipohypertrophy
AU - Mirmirani, Paradi
AU - Maurer, Toby
AU - Cohen, Mardge
AU - D'Souza, Gypsymber
AU - Karim, Roksana
AU - Plankey, Michael
AU - Robison, Esther
AU - Sharma, Anjali
AU - Tien, Phyllis C.
AU - Hessol, Nancy A.
N1 - Publisher Copyright:
© 2013 The International Society of Dermatology.
PY - 2014
Y1 - 2014
N2 - Background: Normal lipid metabolism and functioning of the peroxisome proliferatoractivated receptor gamma (PPAR-gamma) in the sebaceous gland is critical to maintaining a normal hair follicle. Human immunodeficiency virus (HIV) infection affects lipid metabolism; some have hypothesized a link between PPAR-gamma function and lipodystrophy in HIV infection. Our objective was to determine whether lipodystrophy is associated with altered hair characteristics in HIV-infected women from the Women's Interagency HIV Study. Methods: Hair characteristics and scalp inflammation were assessed by an intervieweradministered questionnaire. Central lipohypertrophy and peripheral lipoatrophy were defined by self-report of moderate to severe fat gain in central body sites and fat loss in peripheral body sites, respectively confirmed by clinical examination. Additional covariates considered in the analyses included demographics, behavioral characteristics, medical history, and HIV-related factors. Results: There were 1037 women with data on all study variables; 76 women reported central lipohypertrophy, while only four women reported lipoatrophy. Women with central lipohypertrophy were more likely to be older, had a self-reported history of injection drug use, statin medication use, diabetes, elevated cholesterol, and have self-reported less hair and shorter eyelashes. After adjustment for age, central lipohypertrophy was associated with shorter eyelashes (OR 2.3; 95% CI 1.4-3.8). Conclusions: Central lipohypertrophy was not associated with change in scalp hair texture or scalp inflammation in this cohort. Rather, we found an association between central lipohypertrophy and shorter eyelash length. This finding may be explained by an influence of prostaglandin E2 mediators on eyelash follicles.
AB - Background: Normal lipid metabolism and functioning of the peroxisome proliferatoractivated receptor gamma (PPAR-gamma) in the sebaceous gland is critical to maintaining a normal hair follicle. Human immunodeficiency virus (HIV) infection affects lipid metabolism; some have hypothesized a link between PPAR-gamma function and lipodystrophy in HIV infection. Our objective was to determine whether lipodystrophy is associated with altered hair characteristics in HIV-infected women from the Women's Interagency HIV Study. Methods: Hair characteristics and scalp inflammation were assessed by an intervieweradministered questionnaire. Central lipohypertrophy and peripheral lipoatrophy were defined by self-report of moderate to severe fat gain in central body sites and fat loss in peripheral body sites, respectively confirmed by clinical examination. Additional covariates considered in the analyses included demographics, behavioral characteristics, medical history, and HIV-related factors. Results: There were 1037 women with data on all study variables; 76 women reported central lipohypertrophy, while only four women reported lipoatrophy. Women with central lipohypertrophy were more likely to be older, had a self-reported history of injection drug use, statin medication use, diabetes, elevated cholesterol, and have self-reported less hair and shorter eyelashes. After adjustment for age, central lipohypertrophy was associated with shorter eyelashes (OR 2.3; 95% CI 1.4-3.8). Conclusions: Central lipohypertrophy was not associated with change in scalp hair texture or scalp inflammation in this cohort. Rather, we found an association between central lipohypertrophy and shorter eyelash length. This finding may be explained by an influence of prostaglandin E2 mediators on eyelash follicles.
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U2 - 10.1111/ijd.12044
DO - 10.1111/ijd.12044
M3 - Article
C2 - 23786579
AN - SCOPUS:84907816191
SN - 0011-9059
VL - 53
SP - e443-e448
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 10
ER -