TY - GEN
T1 - Investigating sources of axonal calcium in neuronal cultures modeling Traumatic Brain Injury
AU - Dastgheyb, R. M.
AU - Barbee, K. A.
AU - Gallo, G.
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2015/6/2
Y1 - 2015/6/2
N2 - Increased axonal calcium is a common consequence of Traumatic Brain Injuries (TBIs). Understanding the source of this calcium is important to understanding the injury pathway and developing effective therapies. Here we make calcium measurements in live cells after perturbing pieces of the hypothesized TBI pathway, including inducing membrane damage, mitochondrial dysfunction, and increased oxidative stress. The findings provide evidence for dual sources of calcium, both from extracellular influx and intracellular release.
AB - Increased axonal calcium is a common consequence of Traumatic Brain Injuries (TBIs). Understanding the source of this calcium is important to understanding the injury pathway and developing effective therapies. Here we make calcium measurements in live cells after perturbing pieces of the hypothesized TBI pathway, including inducing membrane damage, mitochondrial dysfunction, and increased oxidative stress. The findings provide evidence for dual sources of calcium, both from extracellular influx and intracellular release.
UR - http://www.scopus.com/inward/record.url?scp=84941033452&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941033452&partnerID=8YFLogxK
U2 - 10.1109/NEBEC.2015.7117156
DO - 10.1109/NEBEC.2015.7117156
M3 - Conference contribution
AN - SCOPUS:84941033452
T3 - 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
BT - 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
Y2 - 17 April 2015 through 19 April 2015
ER -