Investigating sources of axonal calcium in neuronal cultures modeling Traumatic Brain Injury

R. M. Dastgheyb, K. A. Barbee, G. Gallo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Increased axonal calcium is a common consequence of Traumatic Brain Injuries (TBIs). Understanding the source of this calcium is important to understanding the injury pathway and developing effective therapies. Here we make calcium measurements in live cells after perturbing pieces of the hypothesized TBI pathway, including inducing membrane damage, mitochondrial dysfunction, and increased oxidative stress. The findings provide evidence for dual sources of calcium, both from extracellular influx and intracellular release.

Original languageEnglish (US)
Title of host publication2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479983605
DOIs
StatePublished - Jun 2 2015
Externally publishedYes
Event2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States
Duration: Apr 17 2015Apr 19 2015

Publication series

Name2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

Other

Other2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
CountryUnited States
CityTroy
Period4/17/154/19/15

ASJC Scopus subject areas

  • Biotechnology
  • Cancer Research
  • Cell Biology
  • Molecular Medicine
  • Biomedical Engineering
  • Control and Systems Engineering

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