Investigating sources of axonal calcium in neuronal cultures modeling Traumatic Brain Injury

Raha Dastgheyb, K. A. Barbee, G. Gallo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Increased axonal calcium is a common consequence of Traumatic Brain Injuries (TBIs). Understanding the source of this calcium is important to understanding the injury pathway and developing effective therapies. Here we make calcium measurements in live cells after perturbing pieces of the hypothesized TBI pathway, including inducing membrane damage, mitochondrial dysfunction, and increased oxidative stress. The findings provide evidence for dual sources of calcium, both from extracellular influx and intracellular release.

Original languageEnglish (US)
Title of host publication2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479983605
DOIs
StatePublished - Jun 2 2015
Externally publishedYes
Event2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 - Troy, United States
Duration: Apr 17 2015Apr 19 2015

Publication series

Name2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

Other

Other2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015
CountryUnited States
CityTroy
Period4/17/154/19/15

Fingerprint

Calcium
Brain
Oxidative stress
Mitochondrial Membranes
Oxidative Stress
Membranes
Traumatic Brain Injury
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Biotechnology
  • Cancer Research
  • Cell Biology
  • Molecular Medicine
  • Biomedical Engineering
  • Control and Systems Engineering

Cite this

Dastgheyb, R., Barbee, K. A., & Gallo, G. (2015). Investigating sources of axonal calcium in neuronal cultures modeling Traumatic Brain Injury. In 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015 [7117156] (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEBEC.2015.7117156

Investigating sources of axonal calcium in neuronal cultures modeling Traumatic Brain Injury. / Dastgheyb, Raha; Barbee, K. A.; Gallo, G.

2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. 7117156 (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dastgheyb, R, Barbee, KA & Gallo, G 2015, Investigating sources of axonal calcium in neuronal cultures modeling Traumatic Brain Injury. in 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015., 7117156, 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Institute of Electrical and Electronics Engineers Inc., 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015, Troy, United States, 4/17/15. https://doi.org/10.1109/NEBEC.2015.7117156
Dastgheyb R, Barbee KA, Gallo G. Investigating sources of axonal calcium in neuronal cultures modeling Traumatic Brain Injury. In 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc. 2015. 7117156. (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015). https://doi.org/10.1109/NEBEC.2015.7117156
Dastgheyb, Raha ; Barbee, K. A. ; Gallo, G. / Investigating sources of axonal calcium in neuronal cultures modeling Traumatic Brain Injury. 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015. Institute of Electrical and Electronics Engineers Inc., 2015. (2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015).
@inproceedings{9748af4f12bd4056bf3db1c80a84810b,
title = "Investigating sources of axonal calcium in neuronal cultures modeling Traumatic Brain Injury",
abstract = "Increased axonal calcium is a common consequence of Traumatic Brain Injuries (TBIs). Understanding the source of this calcium is important to understanding the injury pathway and developing effective therapies. Here we make calcium measurements in live cells after perturbing pieces of the hypothesized TBI pathway, including inducing membrane damage, mitochondrial dysfunction, and increased oxidative stress. The findings provide evidence for dual sources of calcium, both from extracellular influx and intracellular release.",
author = "Raha Dastgheyb and Barbee, {K. A.} and G. Gallo",
year = "2015",
month = "6",
day = "2",
doi = "10.1109/NEBEC.2015.7117156",
language = "English (US)",
series = "2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015",

}

TY - GEN

T1 - Investigating sources of axonal calcium in neuronal cultures modeling Traumatic Brain Injury

AU - Dastgheyb, Raha

AU - Barbee, K. A.

AU - Gallo, G.

PY - 2015/6/2

Y1 - 2015/6/2

N2 - Increased axonal calcium is a common consequence of Traumatic Brain Injuries (TBIs). Understanding the source of this calcium is important to understanding the injury pathway and developing effective therapies. Here we make calcium measurements in live cells after perturbing pieces of the hypothesized TBI pathway, including inducing membrane damage, mitochondrial dysfunction, and increased oxidative stress. The findings provide evidence for dual sources of calcium, both from extracellular influx and intracellular release.

AB - Increased axonal calcium is a common consequence of Traumatic Brain Injuries (TBIs). Understanding the source of this calcium is important to understanding the injury pathway and developing effective therapies. Here we make calcium measurements in live cells after perturbing pieces of the hypothesized TBI pathway, including inducing membrane damage, mitochondrial dysfunction, and increased oxidative stress. The findings provide evidence for dual sources of calcium, both from extracellular influx and intracellular release.

UR - http://www.scopus.com/inward/record.url?scp=84941033452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941033452&partnerID=8YFLogxK

U2 - 10.1109/NEBEC.2015.7117156

DO - 10.1109/NEBEC.2015.7117156

M3 - Conference contribution

AN - SCOPUS:84941033452

T3 - 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

BT - 2015 41st Annual Northeast Biomedical Engineering Conference, NEBEC 2015

PB - Institute of Electrical and Electronics Engineers Inc.

ER -