TY - JOUR
T1 - Investigating dimensions of stiffness in rheumatoid and psoriatic arthritis
T2 - The australian rheumatology association database registry and OMERACT collaboration
AU - Sinnathurai, Premarani
AU - Bartlett, Susan J.
AU - Halls, Serena
AU - Hewlett, Sarah
AU - Orbai, Ana Maria
AU - Buchbinder, Rachelle
AU - Henderson, Lyndall
AU - Hill, Catherine L.
AU - Lassere, Marissa
AU - March, Lyn
N1 - Funding Information:
From the Institute of Bone and Joint Research, Kolling Institute; Rheumatology Department, Royal North Shore Hospital, St Leonards; Sydney Medical School, University of Sydney; School of Public Health and Community Medicine, University of New South Wales, Sydney; Monash Department of Clinical Epidemiology, Cabrini Institute; Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne; Rheumatology Unit, The Queen Elizabeth Hospital; Discipline of Medicine, University of Adelaide, Adelaide; Rheumatology Department, St George Hospital, Kogarah, Australia; Divisions of Clinical Epidemiology, Rheumatology, and Respiratory Epidemiology, McGill University, Montreal, Quebec, Canada; Division of Rheumatology, Johns Hopkins Medicine, Baltimore, Maryland, USA; Department of Nursing and Midwifery, University of the West of England, Bristol, UK. The Australian Rheumatology Association Database (ARAD) is currently supported by unrestricted educational grants administered through the Australian Rheumatology Association from AbbVie Pty Ltd, Pfizer Australia, Sanofi Australia, Celgene Australia & New Zealand, and Bristol-Myers Squibb Australia Pty Ltd. Previous sponsorship for ARAD included an Australian National Health and Medical Research Council (NHMRC) Enabling Grant (384330), Amgen Australia Pty Ltd, Aventis, AstraZeneca, Roche, Monash University, and Cabrini Health.
Funding Information:
Infrastructure support for ARAD was received from Cabrini Hospital, Royal North Shore Hospital, and the Australian Rheumatology Association. P. Sinnathurai is supported by an NHMRC Postgraduate Scholarship. R. Buchbinder is funded by an NHMRC Senior Principal Research Fellowship. P. Sinnathurai, MBBS, Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, and Department of Rheumatology, Royal North Shore Hospital, and University of Sydney; S.J. Bartlett, MD, Division of Clinical Epidemiology, Division of Rheumatology, and Division of Respiratory Epidemiology, McGill University/McGill University Health Centers, and Division of Rheumatology, Johns Hopkins School of Medicine; S. Halls, PhD, Department of Nursing and Midwifery, University of the West of England; S. Hewlett, PhD, Department of Nursing and Midwifery, University of the West of England; A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; R. Buchbinder, PhD, Monash Department of Clinical Epidemiology, Cabrini Institute, and Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University; L. Henderson, MSc, University of Sydney; C.L. Hill, MD, Rheumatology Unit, The Queen Elizabeth Hospital, and Discipline of Medicine, University of Adelaide; M. Lassere, PhD, School of Public Health and Community Medicine,
Publisher Copyright:
© 2019 Journal of Rheumatology. All rights reserved.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Objective. It is not known how the experience of stiffness varies between diagnoses or how best to measure stiffness. The aims of our study were to (1) compare stiffness in psoriatic arthritis (PsA) and rheumatoid arthritis (RA) using patient-reported outcomes, (2) investigate how dimensions of stiffness are associated with each other and reflect the patient experience, and (3) analyze how different dimensions of stiffness are associated with physical function. Methods. An online survey was sent to Australian Rheumatology Association Database participants (158 PsA, and 158 age- and sex-matched RA), assessing stiffness severity, duration, impact, importance, coping, and physical function [modified Health Assessment Questionnaire (mHAQ)]. Scores were compared between diagnoses and correlations among stiffness dimensions calculated. Multivariate regression was performed for stiffness severity, impact, and duration on mHAQ, adjusting for age, sex, disease duration, obesity, and pain. Cognitive debriefing was conducted through semistructured telephone interviews. Results. Overall, 240/316 (75.9%) responded [124/158 RA (78.5%) and 116/158 PsA (73.4%)], with no significant difference in stiffness ratings between diagnoses. Scores for all stiffness dimensions were strongly correlated (r = 0.52-0.89), and severity and impact were associated with mHAQ in both diagnoses. Stiffness duration was not associated with mHAQ in RA. In cognitive debriefing, participants described stiffness severity and impact by their effect on daily activities (10/16 and 14/16 participants, respectively). Conclusion. Stiffness ratings were similar between PsA and RA. Different dimensions of stiffness were strongly correlated. Stiffness severity and impact both independently predicted mHAQ. Stiffness was important to participants; however, measuring multiple dimensions of stiffness may have minimal additive value.
AB - Objective. It is not known how the experience of stiffness varies between diagnoses or how best to measure stiffness. The aims of our study were to (1) compare stiffness in psoriatic arthritis (PsA) and rheumatoid arthritis (RA) using patient-reported outcomes, (2) investigate how dimensions of stiffness are associated with each other and reflect the patient experience, and (3) analyze how different dimensions of stiffness are associated with physical function. Methods. An online survey was sent to Australian Rheumatology Association Database participants (158 PsA, and 158 age- and sex-matched RA), assessing stiffness severity, duration, impact, importance, coping, and physical function [modified Health Assessment Questionnaire (mHAQ)]. Scores were compared between diagnoses and correlations among stiffness dimensions calculated. Multivariate regression was performed for stiffness severity, impact, and duration on mHAQ, adjusting for age, sex, disease duration, obesity, and pain. Cognitive debriefing was conducted through semistructured telephone interviews. Results. Overall, 240/316 (75.9%) responded [124/158 RA (78.5%) and 116/158 PsA (73.4%)], with no significant difference in stiffness ratings between diagnoses. Scores for all stiffness dimensions were strongly correlated (r = 0.52-0.89), and severity and impact were associated with mHAQ in both diagnoses. Stiffness duration was not associated with mHAQ in RA. In cognitive debriefing, participants described stiffness severity and impact by their effect on daily activities (10/16 and 14/16 participants, respectively). Conclusion. Stiffness ratings were similar between PsA and RA. Different dimensions of stiffness were strongly correlated. Stiffness severity and impact both independently predicted mHAQ. Stiffness was important to participants; however, measuring multiple dimensions of stiffness may have minimal additive value.
KW - Outcomes research
KW - Patient perspective
KW - Psoriatic arthritis
KW - Rheumatoid arthritis
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UR - http://www.scopus.com/inward/citedby.url?scp=85074378212&partnerID=8YFLogxK
U2 - 10.3899/jrheum.181251
DO - 10.3899/jrheum.181251
M3 - Article
C2 - 30936277
AN - SCOPUS:85074378212
SN - 0315-162X
VL - 46
SP - 1462
EP - 1469
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 11
ER -