Inverse electrocardiographic imaging to assess electrical dyssynchrony in cardiac resynchronization therapy patients

Fady Dawoud, David Spragg, Karl H. Schuleri, B. Milan Horáček, Henry Halperin, Albert C. Lardo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Electrical dyssynchrony is postulated to be one of the main factors contributing to non-response of patients to cardiac resynchronization therapy (CRT). We applied inverse epicardial imaging computed from patient-specific geometry and body-surface potential recordings to assess global and regional electrical dyssynchrony. Patients were imaged pre- and post-device implantation, without and with pacing function (P-OFF and P-ON). The reconstructed maps of activation in the dyssynchronous pre-CRT rhythm agree with published contact mapping activation maps with earliest activation starting on the RV free wall and slowly spreading to the LV in a U-shaped pattern. The new ΔQRSi metric captures global pre-CRT dyssynchrony showing negative values (-0.32±0.10) with minimal variability beats (coefficient of variation 10±3.6%) while post-CRT pacing indicates positive values (0.18±0.11). The imaging method is well-suited to study electrical dyssynchrony and potentially guide CRT lead placement.

Original languageEnglish (US)
Title of host publicationComputing in Cardiology 2012, CinC 2012
Pages993-996
Number of pages4
StatePublished - Dec 1 2012
Event39th Computing in Cardiology Conference, CinC 2012 - Krakow, Poland
Duration: Sep 9 2012Sep 12 2012

Publication series

NameComputing in Cardiology
Volume39
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X

Other

Other39th Computing in Cardiology Conference, CinC 2012
Country/TerritoryPoland
CityKrakow
Period9/9/129/12/12

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

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