Abstract
Invasive zygomycosis in neonates and children has both similarities to and differences from that in adults. We searched PubMed and individual references for English-language reports of single cases or case series of neonatal (<1 month) and paediatric (≤18 years) zygomycosis and compared the results with published results in adults. Cases were included if they fulfilled pre-specified criteria. A total of 59 cases of neonatal zygomycosis were reported to July 2007; 157 paediatric cases were published up to 2004 and an additional 30 paediatric cases were reported more recently. Prematurity was a major underlying factor among neonatal cases. The most common manifestations of zygomycosis were gastrointestinal (54%) and cutaneous (36%). This pattern differs from the sinopulmonary and rhinocerebral patterns typical in older children and adults. Overall mortality was 64% in neonates, 56% in children and 53% in adults. A tendency for dissemination was higher in neonates than adults. Dissemination and young age (<1 year) were independent risk factors for death in children. Most patients who survived received antifungal therapy. Surgery combined with antifungal therapy was a protective factor against death. Most neonates and children who survived had received an amphotericin B formulation. Zygomycosis is a life-threatening infection in children and neonates with differing patterns of involvement in individuals of different ages. The most common management strategy in survivors involved a combination of amphotericin B and surgery.
Original language | English (US) |
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Pages (from-to) | 50-54 |
Number of pages | 5 |
Journal | Clinical Microbiology and Infection |
Volume | 15 |
Issue number | SUPPL. 5 |
DOIs | |
State | Published - Oct 2009 |
Externally published | Yes |
Keywords
- Cutaneus zygomycosis
- Gastrointestinal zygomycosis
- Mucormycosis
- Rhizopus spp
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases