Invasive pneumococcal disease caused by nonvaccine serotypes among Alaska Native children with high levels of 7-valent pneumococcal conjugate vaccine coverage

Rosalyn J. Singleton, Thomas W. Hennessy, Lisa R. Bulkow, Laura L Hammitt, Tammy Zulz, Debby A. Hurlburt, Jay C. Butler, Karen Rudolph, Alan Parkinson

Research output: Contribution to journalArticle

Abstract

Context: With routine childhood vaccination using heptavalent pneumococcal conjugate vaccine, one concern has been the potential for emergence and expansion of replacement disease caused by serotypes not contained in the heptavalent conjugate vaccine. Objective: To determine whether replacement disease is associated with the overall decline in invasive pneumococcal disease among Alaska Native children. Design, Setting, and Patients: Alaska statewide longitudinal population-based laboratory surveillance of invasive Streptococcus pneumoniae infections from January 1, 1995, through December 31, 2006. Main Outcome Measures: Incidence and types of pneumococcal disease in children younger than 2 years. Results: In the first 3 years after introduction of routine vaccination with heptavalent pneumococcal conjugate vaccine, overall invasive pneumococcal disease decreased 67% in Alaska Native children younger than 2 years (from 403.2 per 100 000 in 1995-2000 to 134.3 per 100 000 per year in 2001-2003, P

Original languageEnglish (US)
Pages (from-to)1784-1792
Number of pages9
JournalJournal of the American Medical Association
Volume297
Issue number16
DOIs
StatePublished - Apr 25 2007
Externally publishedYes

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Conjugate Vaccines
Pneumococcal Vaccines
Vaccination
Pneumococcal Infections
Outcome Assessment (Health Care)
Serogroup
Alaska Natives
Incidence
Population

ASJC Scopus subject areas

  • Medicine(all)

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Invasive pneumococcal disease caused by nonvaccine serotypes among Alaska Native children with high levels of 7-valent pneumococcal conjugate vaccine coverage. / Singleton, Rosalyn J.; Hennessy, Thomas W.; Bulkow, Lisa R.; Hammitt, Laura L; Zulz, Tammy; Hurlburt, Debby A.; Butler, Jay C.; Rudolph, Karen; Parkinson, Alan.

In: Journal of the American Medical Association, Vol. 297, No. 16, 25.04.2007, p. 1784-1792.

Research output: Contribution to journalArticle

Singleton, Rosalyn J. ; Hennessy, Thomas W. ; Bulkow, Lisa R. ; Hammitt, Laura L ; Zulz, Tammy ; Hurlburt, Debby A. ; Butler, Jay C. ; Rudolph, Karen ; Parkinson, Alan. / Invasive pneumococcal disease caused by nonvaccine serotypes among Alaska Native children with high levels of 7-valent pneumococcal conjugate vaccine coverage. In: Journal of the American Medical Association. 2007 ; Vol. 297, No. 16. pp. 1784-1792.
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