Invasive infection with Saccharomyces cerevisiae: Report of three cases and review

John N. Aucott, John Fayen, Hans Grossnicklas, Anne Morrissey, Michael M. Lederman, Robert A. Salata

Research output: Contribution to journalArticle

Abstract

Saccharomyces cerevisiae (brewer’s or baker’s yeast) is a common colonizer of human mucosal surfaces, but its role as a clinically important pathogen has been unclear. We report three cases of life-threatening invasive infection with S. cerevisiae resulting in pneumonia, liver abscess and sepsis, and disseminated infection with cardiac tamponade, respectively. A review of the English-language literature reveals 14 other cases of saccharomyces infection in humans. Severe immunosuppression, prolonged hospitalization, prior antibiotic therapy, and/or prosthetic cardiac valves are the settings where saccharomyces infection has been observed. Because Saccharomyces can be a common saprophytic contaminant, biopsy and pathologic confirmation of infection are often necessary for a definitive diagnosis. Amphotericin B is the treatment of choice for serious infections with this organism.

Original languageEnglish (US)
Pages (from-to)406-411
Number of pages6
JournalClinical Infectious Diseases
Volume12
Issue number3
DOIs
StatePublished - May 1990
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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