Invasive infection with fusarium chlamydosporum in a patient with aplastic anemia

B. H. Segal, T. J. Walsh, J. M. Liu, J. D. Wilson, K. J. Kwon-Chung

Research output: Contribution to journalArticle

Abstract

We report the first case of invasive disease caused by Fusarium chlamydosporum. The patient had aplastic anemia with prolonged neutropenia and was treated with immunosuppressive therapy. While she was receiving empirical amphotericin B, a dark crusted lesion developed on her nasal turbinate. Histologic analysis revealed invasive hyaline hyphae and some darkly pigmented structures that resembled conidia of dematiaceous molds. Only after the mold was grown in culture were characteristic colonial morphology, phialides, conidia, and chlamydospores evident, thus permitting the identification of F. chlamydosporum. This case illustrates the everincreasing spectrum of pathogenic Fusarium spp. in immunocompromised patients and emphasizes the potential pitfalls in histologic diagnosis, which may have important treatment implications.

Original languageEnglish (US)
Pages (from-to)1772-1776
Number of pages5
JournalJournal of clinical microbiology
Volume36
Issue number6
DOIs
StatePublished - Jan 1 1998

ASJC Scopus subject areas

  • Microbiology (medical)

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