Invasive candidiasis in patients with implants

Research output: Contribution to journalReview article

Abstract

Implantable device infections are an important cause of invasive candidiasis and carry high rates of morbidity and mortality. Central vascular access catheters are by far the most commonly infected type of device. Infections associated with peritoneal dialysis catheters, cardiac devices, prosthetic joints, and other implantable devices are much less common but can have devastating consequences for affected patients. Central to the pathogenesis of these infections is the interplay between altered anatomic barriers due to device implantation, host immune factors, and the tendency of Candida to form biofilms upon inanimate surfaces. Once infection develops, current treatment options nearly always necessitate removal of the device, so major efforts are under way to prevent infection by implementing innovative infection control strategies and developing implants that are less susceptible to biofilm formation. This review focuses on recent developments in our understanding of the epidemiology, pathogenesis, treatment options, and prevention of implant-associated invasive candidiasis.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalCurrent Fungal Infection Reports
Volume5
Issue number1
DOIs
StatePublished - Mar 1 2011

Keywords

  • Biofilm
  • Candida
  • Candidiasis
  • Catheters
  • Devices
  • Fungal infection
  • Implantable

ASJC Scopus subject areas

  • Infectious Diseases

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