Invasive aspergillosis is an important cause of infectious morbidity and mortality in children with innate or acquired deficiencies in phagocytic host defences and anatomical barriers. Similar to adults, it most commonly affects the lung, and remains difficult to diagnose. Prognosis depends on early recognition, prompt institution of appropriate treatment and restoration of host defences. Paediatric patients represent a distinct population in regard to clinical presentation and epidemiology, and in particular, the utility of diagnostic tools such as the serum galactomannan ELISA and high resolution computed tomography scan imaging. The disposition of antifungal agents with clinical efficacy against invasive aspergillosis is different, resulting in different dosages across age groups and differential therapeutic algorithms due to the lack of either published clinical experience or a paediatric dosage as in the setting of antifungal prophylaxis. This chapter reviews presentation and epidemiology of invasive aspergillosis in neonates, children and adolescents and discusses the value of currents diagnostics as well as options for treatment and prevention in these distinct populations.
|Original language||English (US)|
|Title of host publication||Aspergillosis|
|Subtitle of host publication||From Diagnosis to Prevention|
|Number of pages||23|
|State||Published - 2010|
ASJC Scopus subject areas