Invasive adenoma and pituitary carcinoma: A SEER database analysis

Tara M. Hansen, Sachin Batra, Michael Lim, Gary L Gallia, Peter C. Burger, Roberto Salvatori, Gary S Wand, Alfredo Quinones-Hinojosa, Lawrence R Kleinberg, Kristin A Redmond

Research output: Contribution to journalArticle

Abstract

Invasive pituitary adenomas and pituitary carcinomas are clinically indistinguishable until identification of metastases. Optimal management and survival outcomes for both are not clearly defined. The purpose of this study is to use the Surveillance, Epidemiology, and End Results (SEER) database to report patterns of care and compare survival outcomes in a large series of patients with invasive adenomas or pituitary carcinomas. One hundred seventeen patients diagnosed between 1973 and 2008 with pituitary adenomas/adenocarcinomas were included. Eighty-three invasive adenomas and seven pituitary carcinomas were analyzed for survival outcomes. Analyzed prognostic factors included age, sex, race, histology, tumor extent, and treatment. A significant decrease in survival was observed among carcinomas compared to invasive adenomas at 1, 2, and 5 years (p=0.047, 0.001, and 0.009). Only non-white race, male gender, and age ≥65 were significant negative prognostic factors for invasive adenomas (p=0.013, 0.033, and

Original languageEnglish (US)
Pages (from-to)279-286
Number of pages8
JournalNeurosurgical Review
Volume37
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Pituitary Neoplasms
Adenoma
Epidemiology
Databases
Survival
Histology
Adenocarcinoma
Neoplasm Metastasis
Carcinoma
Neoplasms

Keywords

  • Invasive adenoma
  • Pituitary carcinoma
  • Pituitary tumor
  • Survival
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Medicine(all)

Cite this

Invasive adenoma and pituitary carcinoma : A SEER database analysis. / Hansen, Tara M.; Batra, Sachin; Lim, Michael; Gallia, Gary L; Burger, Peter C.; Salvatori, Roberto; Wand, Gary S; Quinones-Hinojosa, Alfredo; Kleinberg, Lawrence R; Redmond, Kristin A.

In: Neurosurgical Review, Vol. 37, No. 2, 2014, p. 279-286.

Research output: Contribution to journalArticle

@article{8f96918f39ba4e89add72ce93de55b4b,
title = "Invasive adenoma and pituitary carcinoma: A SEER database analysis",
abstract = "Invasive pituitary adenomas and pituitary carcinomas are clinically indistinguishable until identification of metastases. Optimal management and survival outcomes for both are not clearly defined. The purpose of this study is to use the Surveillance, Epidemiology, and End Results (SEER) database to report patterns of care and compare survival outcomes in a large series of patients with invasive adenomas or pituitary carcinomas. One hundred seventeen patients diagnosed between 1973 and 2008 with pituitary adenomas/adenocarcinomas were included. Eighty-three invasive adenomas and seven pituitary carcinomas were analyzed for survival outcomes. Analyzed prognostic factors included age, sex, race, histology, tumor extent, and treatment. A significant decrease in survival was observed among carcinomas compared to invasive adenomas at 1, 2, and 5 years (p=0.047, 0.001, and 0.009). Only non-white race, male gender, and age ≥65 were significant negative prognostic factors for invasive adenomas (p=0.013, 0.033, and",
keywords = "Invasive adenoma, Pituitary carcinoma, Pituitary tumor, Survival, Treatment",
author = "Hansen, {Tara M.} and Sachin Batra and Michael Lim and Gallia, {Gary L} and Burger, {Peter C.} and Roberto Salvatori and Wand, {Gary S} and Alfredo Quinones-Hinojosa and Kleinberg, {Lawrence R} and Redmond, {Kristin A}",
year = "2014",
doi = "10.1007/s10143-014-0525-y",
language = "English (US)",
volume = "37",
pages = "279--286",
journal = "Neurosurgical Review",
issn = "0344-5607",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Invasive adenoma and pituitary carcinoma

T2 - A SEER database analysis

AU - Hansen, Tara M.

AU - Batra, Sachin

AU - Lim, Michael

AU - Gallia, Gary L

AU - Burger, Peter C.

AU - Salvatori, Roberto

AU - Wand, Gary S

AU - Quinones-Hinojosa, Alfredo

AU - Kleinberg, Lawrence R

AU - Redmond, Kristin A

PY - 2014

Y1 - 2014

N2 - Invasive pituitary adenomas and pituitary carcinomas are clinically indistinguishable until identification of metastases. Optimal management and survival outcomes for both are not clearly defined. The purpose of this study is to use the Surveillance, Epidemiology, and End Results (SEER) database to report patterns of care and compare survival outcomes in a large series of patients with invasive adenomas or pituitary carcinomas. One hundred seventeen patients diagnosed between 1973 and 2008 with pituitary adenomas/adenocarcinomas were included. Eighty-three invasive adenomas and seven pituitary carcinomas were analyzed for survival outcomes. Analyzed prognostic factors included age, sex, race, histology, tumor extent, and treatment. A significant decrease in survival was observed among carcinomas compared to invasive adenomas at 1, 2, and 5 years (p=0.047, 0.001, and 0.009). Only non-white race, male gender, and age ≥65 were significant negative prognostic factors for invasive adenomas (p=0.013, 0.033, and

AB - Invasive pituitary adenomas and pituitary carcinomas are clinically indistinguishable until identification of metastases. Optimal management and survival outcomes for both are not clearly defined. The purpose of this study is to use the Surveillance, Epidemiology, and End Results (SEER) database to report patterns of care and compare survival outcomes in a large series of patients with invasive adenomas or pituitary carcinomas. One hundred seventeen patients diagnosed between 1973 and 2008 with pituitary adenomas/adenocarcinomas were included. Eighty-three invasive adenomas and seven pituitary carcinomas were analyzed for survival outcomes. Analyzed prognostic factors included age, sex, race, histology, tumor extent, and treatment. A significant decrease in survival was observed among carcinomas compared to invasive adenomas at 1, 2, and 5 years (p=0.047, 0.001, and 0.009). Only non-white race, male gender, and age ≥65 were significant negative prognostic factors for invasive adenomas (p=0.013, 0.033, and

KW - Invasive adenoma

KW - Pituitary carcinoma

KW - Pituitary tumor

KW - Survival

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=84897075231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897075231&partnerID=8YFLogxK

U2 - 10.1007/s10143-014-0525-y

DO - 10.1007/s10143-014-0525-y

M3 - Article

C2 - 24526366

AN - SCOPUS:84897075231

VL - 37

SP - 279

EP - 286

JO - Neurosurgical Review

JF - Neurosurgical Review

SN - 0344-5607

IS - 2

ER -