Invariable presence of stumptailed macaque papovavirus in fetal and adult stumptailed kidney

K. V. Shah, R. W. Daniel, M. Reissig

Research output: Contribution to journalArticle

Abstract

The stumptailed macaque virus (STMV) is a newly recognized, immunologically distinct, papovavirus of the SV40 polyoma subgroup. Because the virus was invariably isolated from kidneys of juvenile and adult stumptailed macaques (Macaca speciosa), we examined kidneys and other tissues from 5 stumptailed and 2 rhesus fetuses of gestational age between 82 and 133 days. Cultures derived from various organs were monitored, with and without further passage for up to 140 days for viral cytopathic effect (CPE), viral immunofluorescence and for virions by electron microscopy. In tests of stumptailed tissues, virus was isolated and immunologically identified from each of 5 kidneys but from none of the cultures derived from skin, lung, brain and placenta. Kidney and skin cultures from both rhesus fetuses were negative. The onset of viral CPE, in positive cultures, occurred between 50 and 75 days. To date, STMV has been isolated from kidneys of each of 29 stumptailed macaques (including 6 fetuses) that have been tested satisfactorily. The invariable presence of the virus in its host, both in fetal and postnatal life, is an unusual feature for a papovavirus. It is not known if the virus is transmitted to the fetus by genetic means or as an infection.

Original languageEnglish (US)
JournalFederation proceedings
Volume35
Issue number3
StatePublished - 1976

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Macaca
Viruses
Kidney
Viral Cytopathogenic Effect
Fetus
Skin
Virion
Placenta
Gestational Age
Fluorescent Antibody Technique
Electron Microscopy
Lung
Brain
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Invariable presence of stumptailed macaque papovavirus in fetal and adult stumptailed kidney. / Shah, K. V.; Daniel, R. W.; Reissig, M.

In: Federation proceedings, Vol. 35, No. 3, 1976.

Research output: Contribution to journalArticle

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AB - The stumptailed macaque virus (STMV) is a newly recognized, immunologically distinct, papovavirus of the SV40 polyoma subgroup. Because the virus was invariably isolated from kidneys of juvenile and adult stumptailed macaques (Macaca speciosa), we examined kidneys and other tissues from 5 stumptailed and 2 rhesus fetuses of gestational age between 82 and 133 days. Cultures derived from various organs were monitored, with and without further passage for up to 140 days for viral cytopathic effect (CPE), viral immunofluorescence and for virions by electron microscopy. In tests of stumptailed tissues, virus was isolated and immunologically identified from each of 5 kidneys but from none of the cultures derived from skin, lung, brain and placenta. Kidney and skin cultures from both rhesus fetuses were negative. The onset of viral CPE, in positive cultures, occurred between 50 and 75 days. To date, STMV has been isolated from kidneys of each of 29 stumptailed macaques (including 6 fetuses) that have been tested satisfactorily. The invariable presence of the virus in its host, both in fetal and postnatal life, is an unusual feature for a papovavirus. It is not known if the virus is transmitted to the fetus by genetic means or as an infection.

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