Introduction to special issue: Challenges and opportunities for regeneration in the peripheral nervous system

Ahmet Höke; Thomas Brushart

doi:10.1016/j.expneurol.2009.12.001

Introduction to special issue: Challenges and opportunities for regeneration in the peripheral nervous system

Ahmet Höke, Thomas Brushart

School of Medicine

Research output: Contribution to journal › Editorial › peer-review

49 Scopus citations

Abstract

Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative capacity is often incomplete and functional recovery with proximal lesions is limited. Furthermore, regeneration of axons to the appropriate targets remains a challenge with inappropriate reinnervation being an impediment to full recovery. The reviews and selected original research papers in this Special Issue will address some of these challenges and highlight new opportunities for development of effective therapies for nerve regeneration.

Original language	English (US)
Pages (from-to)	1-4
Number of pages	4
Journal	Experimental Neurology
Volume	223
Issue number	1
DOIs	https://doi.org/10.1016/j.expneurol.2009.12.001
State	Published - May 2010

Keywords

Chronic denervation
Conditioning lesion
Peripheral nerve regeneration
Preferential motor reinnervation
Schwann cell

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/j.expneurol.2009.12.001

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abstract = "Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative capacity is often incomplete and functional recovery with proximal lesions is limited. Furthermore, regeneration of axons to the appropriate targets remains a challenge with inappropriate reinnervation being an impediment to full recovery. The reviews and selected original research papers in this Special Issue will address some of these challenges and highlight new opportunities for development of effective therapies for nerve regeneration.",

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AB - Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative capacity is often incomplete and functional recovery with proximal lesions is limited. Furthermore, regeneration of axons to the appropriate targets remains a challenge with inappropriate reinnervation being an impediment to full recovery. The reviews and selected original research papers in this Special Issue will address some of these challenges and highlight new opportunities for development of effective therapies for nerve regeneration.

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Introduction to special issue: Challenges and opportunities for regeneration in the peripheral nervous system

Abstract

Keywords

ASJC Scopus subject areas

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