Introduction to positional cloning

Research output: Contribution to journalArticlepeer-review


The most common procedure for isolating genes that predispose to a certain disease is positional cloning. This process is initiated by mapping the responsible gene to its location on a chromosome linked to the disease. Successive cloning of the region results in the isolation of candidate genes. Finally, identification of mutations by mutational analysis points to the correct gene.

Original languageEnglish (US)
Pages (from-to)116-118
Number of pages3
JournalClinical and Experimental Allergy, Supplement
Issue number2
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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