Introduction to genetics and genomics in asthma

Genetics of asthma

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

While asthma is a heterogeneous disease, a strong genetic basis has been firmly established. Rather than being a single disease entity, asthma consists of related, overlapping syndromes [Barnes (Proc Am Thor Soc 8:143-148, 2011)] including three general domains: variable airway obstruction, airway hyperresponsiveness, and airway inflammation with a considerable proportion, but not all, of asthma being IgE-mediated further adding to its heterogeneity. This chapter reviews the approaches to the elucidation of genetics of asthma from the early evidence of familial clustering to the current state of knowledge with genome-wide approaches. The conclusion is that research efforts have led to a tremendous repository of genetic determinants of asthma, most of which fall into the above phenotypic domains of the syndrome. We now look to future integrative approaches of genetics, genomics (Chap. 10), and epigenetics (Chap. 11) to better understand the causal mechanism through which, these genetic loci act in manifesting asthma.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages125-155
Number of pages31
Volume795
ISBN (Print)9781461486022
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume795
ISSN (Print)00652598

Fingerprint

Genomics
Asthma
Immunoglobulin E
Genes
Genetic Loci
Airway Obstruction
Epigenomics
Cluster Analysis
Genetics
Genome
Inflammation
Research

Keywords

  • Asthma
  • Complex traits
  • Genetics
  • Genome-wide association study
  • Heritability
  • Linkage analysis
  • Linkage disequilibrium
  • Population stratification
  • Positional cloning

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Mathias, R. (2014). Introduction to genetics and genomics in asthma: Genetics of asthma. In Advances in Experimental Medicine and Biology (Vol. 795, pp. 125-155). (Advances in Experimental Medicine and Biology; Vol. 795). Springer New York LLC. https://doi.org/10.1007/978-1-4614-8603-9_9

Introduction to genetics and genomics in asthma : Genetics of asthma. / Mathias, Rasika.

Advances in Experimental Medicine and Biology. Vol. 795 Springer New York LLC, 2014. p. 125-155 (Advances in Experimental Medicine and Biology; Vol. 795).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mathias, R 2014, Introduction to genetics and genomics in asthma: Genetics of asthma. in Advances in Experimental Medicine and Biology. vol. 795, Advances in Experimental Medicine and Biology, vol. 795, Springer New York LLC, pp. 125-155. https://doi.org/10.1007/978-1-4614-8603-9_9
Mathias R. Introduction to genetics and genomics in asthma: Genetics of asthma. In Advances in Experimental Medicine and Biology. Vol. 795. Springer New York LLC. 2014. p. 125-155. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-8603-9_9
Mathias, Rasika. / Introduction to genetics and genomics in asthma : Genetics of asthma. Advances in Experimental Medicine and Biology. Vol. 795 Springer New York LLC, 2014. pp. 125-155 (Advances in Experimental Medicine and Biology).
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