Human hemoglobin reacted with bis (3,5-dibromosalicyl) sebacate (XLHb-DEC) forms a stable tetramer and has a plasma half time (PHT) similar to that of other XLHbs, i.e., 3.2 hours. Studies were made to determine if the addition of negative charges to XLHb-DEC would extend its PHT. No increase in PHT was observed but larger urinary excretion of the succinylated species, as compared to XLHb-DEC, suggests that the introduction of negative charges may have led to in vivo instability of the tetramer or the molecule increased the glomerular permeability.
|Original language||English (US)|
|Journal||Artificial Cells, Blood Substitutes, and Immobilization Biotechnology|
|State||Published - Nov 1 1994|
|Event||Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA|
Duration: Jul 24 1994 → Jul 27 1994
ASJC Scopus subject areas
- Biomedical Engineering