Introduction of negative charge on the in vivo behavior of a hemoglobin crosslinked with bis (3,5-dibromosalicyl) sebacate

M. Thomas, B. Urbaitis, Y. Yu, E. Bucci, C. Fronticelli

Research output: Contribution to journalConference articlepeer-review

Abstract

Human hemoglobin reacted with bis (3,5-dibromosalicyl) sebacate (XLHb-DEC) forms a stable tetramer and has a plasma half time (PHT) similar to that of other XLHbs, i.e., 3.2 hours. Studies were made to determine if the addition of negative charges to XLHb-DEC would extend its PHT. No increase in PHT was observed but larger urinary excretion of the succinylated species, as compared to XLHb-DEC, suggests that the introduction of negative charges may have led to in vivo instability of the tetramer or the molecule increased the glomerular permeability.

Original languageEnglish (US)
Pages (from-to)A170
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1 1994
Externally publishedYes
EventProceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA
Duration: Jul 24 1994Jul 27 1994

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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