Introduction of five potentially metabolizable linking groups between 111In-cyclohexyl EDTA derivatives and F(ab′)2 fragments of anti-carcinoembryonic antigen antibody-II. Comparative pharmacokinetics and biodistribution in human colorectal carcinoma-bearing nude mice

A. Faivre-chauvet; J. F. Gestin; R. C. Mease; C. Sai-maurel; P. Thédrez; M. Slinkin; G. E. Meinken; S. C. Srivastava; J. F. Chatal

doi:10.1016/0969-8051(93)90163-O

Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-II. Comparative pharmacokinetics and biodistribution in human colorectal carcinoma-bearing nude mice

A. Faivre-chauvet, J. F. Gestin, R. C. Mease, C. Sai-maurel, P. Thédrez, M. Slinkin, G. E. Meinken, S. C. Srivastava, J. F. Chatal

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The five linker-containing immunoconjugates described in the preceding paper were labeled with ¹¹¹In and tested for their biodistribution, pharmacokinetics and immunoscintigraphic imaging properties in tumor-xenografted nude mice. The results were compared with DTPADA and CDTAMA for reference. Results showed that, for immunoscintigraphy, the derivatives in decreasing order of effectiveness were: aliphatic (tumor/liver > 4.5 and tumor/kidney > 6.5 at 96 h), thioether (tumor/liver > 3 and tumor/kidney > 1.2 at 24 h), ethylene glycol succinate (tumor/liver > 1.7 and tumor/kidney > 0.5 at 24 h) and disulfide (tumor/liver > 0.5 and tumor/kidney > 0.6 at 96 h). Pharmacokinetic results were complementary with those of the biodistribution studies and provide a basis for the study of in vivo metabolic mechanisms of linker-immunoconjugates. Indium-111-labeled linker-immunoconjugates appear promising for tumor imaging with better contrast than what is obtained with the use of the conventional ¹¹¹In-DTPA dianhydride chelate.

Original language	English (US)
Pages (from-to)	763-771
Number of pages	9
Journal	Nuclear Medicine and Biology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/0969-8051(93)90163-O
State	Published - Aug 1993
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

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Faivre-chauvet, A., Gestin, J. F., Mease, R. C., Sai-maurel, C., Thédrez, P., Slinkin, M., Meinken, G. E., Srivastava, S. C., & Chatal, J. F. (1993). Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-II. Comparative pharmacokinetics and biodistribution in human colorectal carcinoma-bearing nude mice. Nuclear Medicine and Biology, 20(6), 763-771. https://doi.org/10.1016/0969-8051(93)90163-O

Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-II. Comparative pharmacokinetics and biodistribution in human colorectal carcinoma-bearing nude mice. / Faivre-chauvet, A.; Gestin, J. F.; Mease, R. C. et al.
In: Nuclear Medicine and Biology, Vol. 20, No. 6, 08.1993, p. 763-771.

Research output: Contribution to journal › Article › peer-review

Faivre-chauvet, A, Gestin, JF, Mease, RC, Sai-maurel, C, Thédrez, P, Slinkin, M, Meinken, GE, Srivastava, SC & Chatal, JF 1993, 'Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-II. Comparative pharmacokinetics and biodistribution in human colorectal carcinoma-bearing nude mice', Nuclear Medicine and Biology, vol. 20, no. 6, pp. 763-771. https://doi.org/10.1016/0969-8051(93)90163-O

Faivre-chauvet A, Gestin JF, Mease RC, Sai-maurel C, Thédrez P, Slinkin M et al. Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-II. Comparative pharmacokinetics and biodistribution in human colorectal carcinoma-bearing nude mice. Nuclear Medicine and Biology. 1993 Aug;20(6):763-771. doi: 10.1016/0969-8051(93)90163-O

Faivre-chauvet, A. ; Gestin, J. F. ; Mease, R. C. et al. / Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-II. Comparative pharmacokinetics and biodistribution in human colorectal carcinoma-bearing nude mice. In: Nuclear Medicine and Biology. 1993 ; Vol. 20, No. 6. pp. 763-771.

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