Introduction of five potentially metabolizable linking groups between 111In-cyclohexyl EDTA derivatives and F(ab′)2 fragments of anti-carcinoembryonic antigen antibody-I. A new reproducible synthetic method

J. F. Gestin; A. Faivre-chauvet; R. C. Mease; C. Sai-maurel; P. Thédrez; M. Slinkin; G. E. Meinken; S. C. Srivastava; J. F. Chatal

doi:10.1016/0969-8051(93)90162-N

Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-I. A new reproducible synthetic method

J. F. Gestin, A. Faivre-chauvet, R. C. Mease, C. Sai-maurel, P. Thédrez, M. Slinkin, G. E. Meinken, S. C. Srivastava, J. F. Chatal

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of ¹¹¹In-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab′)₂ fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with ¹¹¹In with good retention of immunoreactivity.

Original language	English (US)
Pages (from-to)	755-762
Number of pages	8
Journal	Nuclear Medicine and Biology
Volume	20
Issue number	6
DOIs	https://doi.org/10.1016/0969-8051(93)90162-N
State	Published - Aug 1993
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

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Gestin, J. F., Faivre-chauvet, A., Mease, R. C., Sai-maurel, C., Thédrez, P., Slinkin, M., Meinken, G. E., Srivastava, S. C., & Chatal, J. F. (1993). Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-I. A new reproducible synthetic method. Nuclear Medicine and Biology, 20(6), 755-762. https://doi.org/10.1016/0969-8051(93)90162-N

Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-I. A new reproducible synthetic method. / Gestin, J. F.; Faivre-chauvet, A.; Mease, R. C. et al.
In: Nuclear Medicine and Biology, Vol. 20, No. 6, 08.1993, p. 755-762.

Research output: Contribution to journal › Article › peer-review

Gestin, JF, Faivre-chauvet, A, Mease, RC, Sai-maurel, C, Thédrez, P, Slinkin, M, Meinken, GE, Srivastava, SC & Chatal, JF 1993, 'Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-I. A new reproducible synthetic method', Nuclear Medicine and Biology, vol. 20, no. 6, pp. 755-762. https://doi.org/10.1016/0969-8051(93)90162-N

Gestin JF, Faivre-chauvet A, Mease RC, Sai-maurel C, Thédrez P, Slinkin M et al. Introduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab′)₂ fragments of anti-carcinoembryonic antigen antibody-I. A new reproducible synthetic method. Nuclear Medicine and Biology. 1993 Aug;20(6):755-762. doi: 10.1016/0969-8051(93)90162-N

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abstract = "The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of 111In-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab′)2 fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with 111In with good retention of immunoreactivity.",

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