Introduction of five potentially metabolizable linking groups between 111In-cyclohexyl EDTA derivatives and F(ab′)2 fragments of anti-carcinoembryonic antigen antibody-I. A new reproducible synthetic method

J. F. Gestin, A. Faivre-chauvet, R. C. Mease, C. Sai-maurel, P. Thédrez, M. Slinkin, G. E. Meinken, S. C. Srivastava, J. F. Chatal

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of 111In-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab′)2 fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with 111In with good retention of immunoreactivity.

Original languageEnglish (US)
Pages (from-to)755-762
Number of pages8
JournalNuclear Medicine and Biology
Volume20
Issue number6
DOIs
StatePublished - Aug 1993
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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