Introduction and spread of multi-resistant Shigella dysenteriae I in Thailand

D. N. Taylor, L. Bodhidatta, J. E. Brown, P. Echeverria, C. Kunanusont, P. Naigowit, S. Hanchalay, A. Chatkaeomorakot, A. A. Lindberg

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Abstract

Outbreaks of Shigella dysenteriae I occurred in northeastern Thailand in the fall of 1986 and again in the spring and fall of 1987 for the first time in over 20 years. The epidemic strain of S. dysenteriae I was resistant to tetracycline, streptomycin, chloramphenicol, and trimethoprim-sulfamethoxazole, but susceptible to ampicillin. Trimethoprim resistance was chromosomally encoded by type I dihydrofolate reductase. In Ubon Province, where 10,000 cases of dysentery were reported, there were 3-5 cases of dysentery per 1,000 residents during the peak months, with 2-5 hospitalizations per 100 cases of reported dysentery. There were 2 deaths among 101 hospitalized, culture-confirmed cases. The overall case-fatality rate among reported cases of dysentery in this province was 0.9%. In contrast to S. flexneri infections, which occurred predominantly among children

Original languageEnglish (US)
Pages (from-to)77-85
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume40
Issue number1
Publication statusPublished - 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Taylor, D. N., Bodhidatta, L., Brown, J. E., Echeverria, P., Kunanusont, C., Naigowit, P., ... Lindberg, A. A. (1989). Introduction and spread of multi-resistant Shigella dysenteriae I in Thailand. American Journal of Tropical Medicine and Hygiene, 40(1), 77-85.