Introduction and spread of multi-resistant Shigella dysenteriae I in Thailand

D. N. Taylor, L. Bodhidatta, J. E. Brown, P. Echeverria, C. Kunanusont, P. Naigowit, S. Hanchalay, A. Chatkaeomorakot, A. A. Lindberg

Research output: Contribution to journalArticle

Abstract

Outbreaks of Shigella dysenteriae I occurred in northeastern Thailand in the fall of 1986 and again in the spring and fall of 1987 for the first time in over 20 years. The epidemic strain of S. dysenteriae I was resistant to tetracycline, streptomycin, chloramphenicol, and trimethoprim-sulfamethoxazole, but susceptible to ampicillin. Trimethoprim resistance was chromosomally encoded by type I dihydrofolate reductase. In Ubon Province, where 10,000 cases of dysentery were reported, there were 3-5 cases of dysentery per 1,000 residents during the peak months, with 2-5 hospitalizations per 100 cases of reported dysentery. There were 2 deaths among 101 hospitalized, culture-confirmed cases. The overall case-fatality rate among reported cases of dysentery in this province was 0.9%. In contrast to S. flexneri infections, which occurred predominantly among children

Original languageEnglish (US)
Pages (from-to)77-85
Number of pages9
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume40
Issue number1
StatePublished - 1989
Externally publishedYes

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Shigella dysenteriae
Dysentery
Thailand
Trimethoprim Resistance
Tetrahydrofolate Dehydrogenase
Sulfamethoxazole Drug Combination Trimethoprim
Streptomycin
Chloramphenicol
Ampicillin
Tetracycline
Disease Outbreaks
Hospitalization
Mortality
Infection

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Taylor, D. N., Bodhidatta, L., Brown, J. E., Echeverria, P., Kunanusont, C., Naigowit, P., ... Lindberg, A. A. (1989). Introduction and spread of multi-resistant Shigella dysenteriae I in Thailand. American Journal of Tropical Medicine and Hygiene, 40(1), 77-85.

Introduction and spread of multi-resistant Shigella dysenteriae I in Thailand. / Taylor, D. N.; Bodhidatta, L.; Brown, J. E.; Echeverria, P.; Kunanusont, C.; Naigowit, P.; Hanchalay, S.; Chatkaeomorakot, A.; Lindberg, A. A.

In: American Journal of Tropical Medicine and Hygiene, Vol. 40, No. 1, 1989, p. 77-85.

Research output: Contribution to journalArticle

Taylor, DN, Bodhidatta, L, Brown, JE, Echeverria, P, Kunanusont, C, Naigowit, P, Hanchalay, S, Chatkaeomorakot, A & Lindberg, AA 1989, 'Introduction and spread of multi-resistant Shigella dysenteriae I in Thailand', American Journal of Tropical Medicine and Hygiene, vol. 40, no. 1, pp. 77-85.
Taylor DN, Bodhidatta L, Brown JE, Echeverria P, Kunanusont C, Naigowit P et al. Introduction and spread of multi-resistant Shigella dysenteriae I in Thailand. American Journal of Tropical Medicine and Hygiene. 1989;40(1):77-85.
Taylor, D. N. ; Bodhidatta, L. ; Brown, J. E. ; Echeverria, P. ; Kunanusont, C. ; Naigowit, P. ; Hanchalay, S. ; Chatkaeomorakot, A. ; Lindberg, A. A. / Introduction and spread of multi-resistant Shigella dysenteriae I in Thailand. In: American Journal of Tropical Medicine and Hygiene. 1989 ; Vol. 40, No. 1. pp. 77-85.
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