Intrinsic aerobic capacity sets a divide for aging and longevity

Lauren Gerard Koch, Ole J. Kemi, Nathan Qi, Sean Leng, Piter Bijma, Lori J. Gilligan, John E. Wilkinson, Helene Wisløff, Morten A. Høydal, Natale Rolim, Peter Abadir, Elizabeth M. Van Grevenhof, Godfrey L. Smith, Charles F. Burant, Øyvind Ellingsen, Steven L. Britton, Ulrik Wisløff

Research output: Contribution to journalArticle

Abstract

Rationale: Low aerobic exercise capacity is a powerful predictor of premature morbidity and mortality for healthy adults as well as those with cardiovascular disease. For aged populations, poor performance on treadmill or extended walking tests indicates closer proximity to future health declines. Together, these findings suggest a fundamental connection between aerobic capacity and longevity. OBJECTIVES:: Through artificial selective breeding, we developed an animal model system to prospectively test the association between aerobic exercise capacity and survivability (aerobic hypothesis). Methods and Results: Laboratory rats of widely diverse genetic backgrounds (N:NIH stock) were selectively bred for low or high intrinsic (inborn) treadmill running capacity. Cohorts of male and female rats from generations 14, 15, and 17 of selection were followed for survivability and assessed for age-related declines in cardiovascular fitness including maximal oxygen uptake (VO 2max), myocardial function, endurance performance, and change in body mass. Median lifespan for low exercise capacity rats was 28% to 45% shorter than high capacity rats (hazard ratio, 0.06; P2max, measured across adulthood was a reliable predictor of lifespan (P2), and lean body mass were all better sustained with age in rats bred for high aerobic capacity. Conclusions: These data obtained from a contrasting heterogeneous model system provide strong evidence that genetic segregation for aerobic exercise capacity can be linked with longevity and are useful for deeper mechanistic exploration of aging.

Original languageEnglish (US)
Pages (from-to)1162-1172
Number of pages11
JournalCirculation Research
Volume109
Issue number10
DOIs
StatePublished - Oct 28 2011

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Exercise
Premature Mortality
Running
Walking
Cardiovascular Diseases
Animal Models
Oxygen
Morbidity
Health
Population
Selective Breeding
Genetic Background

Keywords

  • aging
  • cardiomyocyte function
  • exercise capacity
  • longevity
  • rat models

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Koch, L. G., Kemi, O. J., Qi, N., Leng, S., Bijma, P., Gilligan, L. J., ... Wisløff, U. (2011). Intrinsic aerobic capacity sets a divide for aging and longevity. Circulation Research, 109(10), 1162-1172. https://doi.org/10.1161/CIRCRESAHA.111.253807

Intrinsic aerobic capacity sets a divide for aging and longevity. / Koch, Lauren Gerard; Kemi, Ole J.; Qi, Nathan; Leng, Sean; Bijma, Piter; Gilligan, Lori J.; Wilkinson, John E.; Wisløff, Helene; Høydal, Morten A.; Rolim, Natale; Abadir, Peter; Van Grevenhof, Elizabeth M.; Smith, Godfrey L.; Burant, Charles F.; Ellingsen, Øyvind; Britton, Steven L.; Wisløff, Ulrik.

In: Circulation Research, Vol. 109, No. 10, 28.10.2011, p. 1162-1172.

Research output: Contribution to journalArticle

Koch, LG, Kemi, OJ, Qi, N, Leng, S, Bijma, P, Gilligan, LJ, Wilkinson, JE, Wisløff, H, Høydal, MA, Rolim, N, Abadir, P, Van Grevenhof, EM, Smith, GL, Burant, CF, Ellingsen, Ø, Britton, SL & Wisløff, U 2011, 'Intrinsic aerobic capacity sets a divide for aging and longevity', Circulation Research, vol. 109, no. 10, pp. 1162-1172. https://doi.org/10.1161/CIRCRESAHA.111.253807
Koch, Lauren Gerard ; Kemi, Ole J. ; Qi, Nathan ; Leng, Sean ; Bijma, Piter ; Gilligan, Lori J. ; Wilkinson, John E. ; Wisløff, Helene ; Høydal, Morten A. ; Rolim, Natale ; Abadir, Peter ; Van Grevenhof, Elizabeth M. ; Smith, Godfrey L. ; Burant, Charles F. ; Ellingsen, Øyvind ; Britton, Steven L. ; Wisløff, Ulrik. / Intrinsic aerobic capacity sets a divide for aging and longevity. In: Circulation Research. 2011 ; Vol. 109, No. 10. pp. 1162-1172.
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