Intravoxel incoherent motion (IVIM) imaging in human achilles tendon

Kenneth Wengler, Takeshi Fukuda, Dharmesh Tank, Mingqian Huang, Elaine S. Gould, Mark E. Schweitzer, Xiang He

Research output: Contribution to journalArticle

Abstract

Background: Limited microcirculation has been implicated in Achilles tendinopathy and may affect healing and disease progression. Existing invasive and noninvasive approaches to evaluate tendon microcirculation lack sensitivity and spatial coverage. Purpose: To develop a novel Achilles tendon intravoxel incoherent motion (IVIM) MRI protocol to overcome the limitations from low tendon T 2 /T 2 * value and low intratendinous blood volume and blood velocity to evaluate tendon microcirculation. Study Type: Prospective. Subjects: Sixteen healthy male participants (age 31.0 ± 2.1) were recruited. Field Strength/Sequence: A stimulated echo readout-segmented echo planar imaging (ste-RS-EPI) IVIM sequence at 3.0T. Assessment: The feasibility of the proposed ste-RS-EPI IVIM protocol combined with Achilles tendon magic angle effect was evaluated. The sensitivity of the protocol was assessed by an exercise-induced intratendinous hemodynamic response in healthy participants. The vascular origin of the observed IVIM signal was validated by varying the diffusion mixing time and echo time. Statistical Tests: Two-tailed t-tests were used to evaluate differences (P < 0.05 was considered significant). Results: Consistent with known tendon hypovascularity, the midportion Achilles tendon at baseline showed significantly lower IVIM-derived perfusion fraction (f p ) (3.1 ± 0.9%) compared to the proximal and distal Achilles tendon (6.0 ± 1.8% and 6.1 ± 2.0%, respectively; P < 0.01). Similarly, the midportion Achilles tendon exhibited significantly lower baseline blood flow index (D*×f p ) (40.9 ± 19.2, 18.3 ± 5.3, and 32.0 ± 9.4 in proximal, midportion, and distal Achilles tendon, respectively; P < 0.01). Eccentric heel-raise exercise led to ∼2 times increase of Achilles tendon blood flow in healthy participants. Consistent with its vascular origin, the estimated f p demonstrated a high dependency to IVIM protocol parameters, while the T 1 /T 2 -corrected absolute intratendinous microvascular blood volume fraction (V b ) did not vary. Data Conclusion: Achilles tendon ste-RS-EPI IVIM noninvasively assessed baseline values and exercise-induced changes to tendon microcirculation in healthy tendon. Level of Evidence: 1. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2018;48:1690–1699.

Original languageEnglish (US)
Pages (from-to)1690-1699
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume48
Issue number6
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

Fingerprint

Achilles Tendon
Tendons
Microcirculation
Echo-Planar Imaging
Healthy Volunteers
Exercise
Blood Volume
Blood Vessels
Tendinopathy
Heel
Disease Progression
Perfusion
Hemodynamics
Prospective Studies

Keywords

  • Achilles tendon
  • intravoxel incoherent motion imaging
  • IVIM
  • RS-EPI
  • stimulated echo
  • tendinopathy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Wengler, K., Fukuda, T., Tank, D., Huang, M., Gould, E. S., Schweitzer, M. E., & He, X. (2018). Intravoxel incoherent motion (IVIM) imaging in human achilles tendon. Journal of Magnetic Resonance Imaging, 48(6), 1690-1699. https://doi.org/10.1002/jmri.26182

Intravoxel incoherent motion (IVIM) imaging in human achilles tendon. / Wengler, Kenneth; Fukuda, Takeshi; Tank, Dharmesh; Huang, Mingqian; Gould, Elaine S.; Schweitzer, Mark E.; He, Xiang.

In: Journal of Magnetic Resonance Imaging, Vol. 48, No. 6, 01.12.2018, p. 1690-1699.

Research output: Contribution to journalArticle

Wengler, K, Fukuda, T, Tank, D, Huang, M, Gould, ES, Schweitzer, ME & He, X 2018, 'Intravoxel incoherent motion (IVIM) imaging in human achilles tendon', Journal of Magnetic Resonance Imaging, vol. 48, no. 6, pp. 1690-1699. https://doi.org/10.1002/jmri.26182
Wengler, Kenneth ; Fukuda, Takeshi ; Tank, Dharmesh ; Huang, Mingqian ; Gould, Elaine S. ; Schweitzer, Mark E. ; He, Xiang. / Intravoxel incoherent motion (IVIM) imaging in human achilles tendon. In: Journal of Magnetic Resonance Imaging. 2018 ; Vol. 48, No. 6. pp. 1690-1699.
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abstract = "Background: Limited microcirculation has been implicated in Achilles tendinopathy and may affect healing and disease progression. Existing invasive and noninvasive approaches to evaluate tendon microcirculation lack sensitivity and spatial coverage. Purpose: To develop a novel Achilles tendon intravoxel incoherent motion (IVIM) MRI protocol to overcome the limitations from low tendon T 2 /T 2 * value and low intratendinous blood volume and blood velocity to evaluate tendon microcirculation. Study Type: Prospective. Subjects: Sixteen healthy male participants (age 31.0 ± 2.1) were recruited. Field Strength/Sequence: A stimulated echo readout-segmented echo planar imaging (ste-RS-EPI) IVIM sequence at 3.0T. Assessment: The feasibility of the proposed ste-RS-EPI IVIM protocol combined with Achilles tendon magic angle effect was evaluated. The sensitivity of the protocol was assessed by an exercise-induced intratendinous hemodynamic response in healthy participants. The vascular origin of the observed IVIM signal was validated by varying the diffusion mixing time and echo time. Statistical Tests: Two-tailed t-tests were used to evaluate differences (P < 0.05 was considered significant). Results: Consistent with known tendon hypovascularity, the midportion Achilles tendon at baseline showed significantly lower IVIM-derived perfusion fraction (f p ) (3.1 ± 0.9{\%}) compared to the proximal and distal Achilles tendon (6.0 ± 1.8{\%} and 6.1 ± 2.0{\%}, respectively; P < 0.01). Similarly, the midportion Achilles tendon exhibited significantly lower baseline blood flow index (D*×f p ) (40.9 ± 19.2, 18.3 ± 5.3, and 32.0 ± 9.4 in proximal, midportion, and distal Achilles tendon, respectively; P < 0.01). Eccentric heel-raise exercise led to ∼2 times increase of Achilles tendon blood flow in healthy participants. Consistent with its vascular origin, the estimated f p demonstrated a high dependency to IVIM protocol parameters, while the T 1 /T 2 -corrected absolute intratendinous microvascular blood volume fraction (V b ) did not vary. Data Conclusion: Achilles tendon ste-RS-EPI IVIM noninvasively assessed baseline values and exercise-induced changes to tendon microcirculation in healthy tendon. Level of Evidence: 1. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2018;48:1690–1699.",
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