Intravitreous Fibronectin and Platelet-Derived Growth Factor: New Model for Traction Retinal Detachment

Julia Haller Yeo, Jahangir Sadeghi, Peter A. Campochiaro, W. Richard Green, Bert M. Glaser

Research output: Contribution to journalArticle

Abstract

In proliferative vitreoretinopathy and trauma, traction retinal detachments result from cellular migration into the vitreous cavity with contractile membrane formation. Cleary and Ryan have established the efficacy of intravitreous injection of autologous blood in reproducing this pathologic process in the rabbit eye. It has previously been shown that two serum components, fibronectin and platelet-derived growth factor, stimulate cellular migration. We now show that contractile membranes and traction retinal detachments occur in 72% of rabbit eyes within three weeks following intravitreous injection of fibronectin and plateletderived growth factor. These results provide a straightforward new model to study the development of intravitreous cellular membranes and traction retinal detachments.

Original languageEnglish (US)
Pages (from-to)417-421
Number of pages5
JournalArchives of ophthalmology
Volume104
Issue number3
DOIs
StatePublished - Mar 1986

ASJC Scopus subject areas

  • Ophthalmology

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