TY - JOUR
T1 - Intravitreous Fibronectin and Platelet-Derived Growth Factor
T2 - New Model for Traction Retinal Detachment
AU - Yeo, Julia Haller
AU - Sadeghi, Jahangir
AU - Campochiaro, Peter A.
AU - Green, W. Richard
AU - Glaser, Bert M.
PY - 1986/3
Y1 - 1986/3
N2 - In proliferative vitreoretinopathy and trauma, traction retinal detachments result from cellular migration into the vitreous cavity with contractile membrane formation. Cleary and Ryan have established the efficacy of intravitreous injection of autologous blood in reproducing this pathologic process in the rabbit eye. It has previously been shown that two serum components, fibronectin and platelet-derived growth factor, stimulate cellular migration. We now show that contractile membranes and traction retinal detachments occur in 72% of rabbit eyes within three weeks following intravitreous injection of fibronectin and plateletderived growth factor. These results provide a straightforward new model to study the development of intravitreous cellular membranes and traction retinal detachments.
AB - In proliferative vitreoretinopathy and trauma, traction retinal detachments result from cellular migration into the vitreous cavity with contractile membrane formation. Cleary and Ryan have established the efficacy of intravitreous injection of autologous blood in reproducing this pathologic process in the rabbit eye. It has previously been shown that two serum components, fibronectin and platelet-derived growth factor, stimulate cellular migration. We now show that contractile membranes and traction retinal detachments occur in 72% of rabbit eyes within three weeks following intravitreous injection of fibronectin and plateletderived growth factor. These results provide a straightforward new model to study the development of intravitreous cellular membranes and traction retinal detachments.
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U2 - 10.1001/archopht.1986.01050150119041
DO - 10.1001/archopht.1986.01050150119041
M3 - Article
C2 - 3954643
AN - SCOPUS:0022593122
SN - 0003-9950
VL - 104
SP - 417
EP - 421
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 3
ER -