Intravitreous and plasma concentrations of ganciclovir and foscarnet after intravenous therapy in patients with aids and cytomegalovirus retinitis

J. Fernando Arevalo, Casimiro Gonzalez, Edmund V. Capparelli, Leonard S. Kirsch, Roberto F. Garcia, Jose I. Quiceno, James D. Connor, John Gambertoglio, Germaine Bergeron-Lynn, William R. Freeman

Research output: Contribution to journalArticle

Abstract

This study evaluated intravitreous and plasma ganciclovir and foscarnet concentrations after intravenous administration in AIDS patients with cytomegalovirus (CMV) retinitis and retinal detachment. Undiluted vitreous samples were prospectively obtained from 60 eyes (52 patients) at the time of pars plana vitrectomy. Thirty-three plasma samples (from 27 patients in the initial group of 52) were obtained simultaneously during surgery on 33 eyes. High-pressure liquid chromatography showed the mean vitreous ganciclovir concentrations in patients on induction and maintenance therapy were, respectively, 4.74 ± 1.49 �M (n = 24) and 3.29 ± 1.84 �M (n = 30; P =.005). Simultaneous plasma ganciclovir concentrations were less than the vitreous concentrations in 78% of the patients. The mean intravitreous foscarnet concentrations in patients receiving induction dosages were 189 ± 177 μM (n = 5) versus 163 ± 167 �M (n = 4; P =.20) for those receiving maintenance therapy. The foscarnet vitreous plasma concentration ratio averaged 1.43. Current drugs and doses for CMV retinitis result in borderline or progressively subtherapeutic concentrations.

Original languageEnglish (US)
Pages (from-to)951-956
Number of pages6
JournalJournal of Infectious Diseases
Volume172
Issue number4
DOIs
StatePublished - Oct 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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  • Cite this

    Arevalo, J. F., Gonzalez, C., Capparelli, E. V., Kirsch, L. S., Garcia, R. F., Quiceno, J. I., Connor, J. D., Gambertoglio, J., Bergeron-Lynn, G., & Freeman, W. R. (1995). Intravitreous and plasma concentrations of ganciclovir and foscarnet after intravenous therapy in patients with aids and cytomegalovirus retinitis. Journal of Infectious Diseases, 172(4), 951-956. https://doi.org/10.1093/infdis/172.4.951