Intravitreal Triamcinolone Acetonide Injection in a Rodent Model of Anterior Ischemic Optic Neuropathy

Luciano S. Pereira, Marcos P. Ávila, Luciana X. Salustiano, Alcio C. Paula, Emmanuel Arnhold, Timothy J. McCulley

Research output: Contribution to journalArticlepeer-review

Abstract

The management of nonarteritic anterior ischemic optic neuropathy centers around prevention of second eye involvement, without a uniformly accepted therapy for the involved eye. Several researchers have assessed the benefit of steroids with conflicting results. This experimental study was designed to evaluate the efficacy of a single intravitreal triamcinolone acetonide injection (IVTA) in preserving retinal ganglion cells (RGCs) in a rodent model of anterior ischemic optic neuropathy (rAION).Methods:The rAION was induced in female Wistar rats. Animals were randomized into 3 groups: 1) untreated, 2) treated with 56 g IVTA, and 3) intravitreal saline (placebo). Procedures were performed in the left eye, with the right eye serving as control. After 30 days, animals were sacrificed and eyes were assessed histologically for RGC number.Results:The average number of RGC was significantly lower in rAION subgroups when compared with the control group (P < 0.001). No significant difference was seen between rAION eyes treated with IVTA, placebo, and untreated eyes (P > 0.05%).Conclusions:In this rodent model for AION, no therapeutic benefit of intravitreal steroid injection was identified.

Original languageEnglish (US)
Pages (from-to)561-565
Number of pages5
JournalJournal of Neuro-Ophthalmology
Volume38
Issue number4
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Ophthalmology
  • Clinical Neurology

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