Intravitreal Delivery of Ganciclovir in Rabbits by Transscleral Iontophoresis

Tim T. Lam, ju fu, Ralph Chu, Kris Stojack, Edward Siew, Mark O.m. Tso

Research output: Contribution to journalArticlepeer-review

Abstract

To avoid the side effects of systemic administration of ganciclovir (GCV) for the treatment of cytomegalovirus (CMV) retinitis, we studied transscleral iontophoresis of GCV into rabbit eyes. After a single application with 20% (w/w) aqueous solution of GCV at 1.0 mA for 15 min gave a vitreal/retinal level of GCV at 74±17 ug/ml at 2 hours as determined by HPLC. At 24 hours after iontophoresis the vitreal/retinal level was above therapeutic level at 4.2±0.6 ug/ml. At 72 hours, there was still detectable level in the vitreous/retina. Hence, transscleral iontophoresis is able to deliver effective dose of GCV into the vitreous. Multiple applications of iontophoresis should be examined as a possible means of CMV treatment.

Original languageEnglish (US)
Pages (from-to)571-575
Number of pages5
JournalJournal of Ocular Pharmacology
Volume10
Issue number3
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Intravitreal Delivery of Ganciclovir in Rabbits by Transscleral Iontophoresis'. Together they form a unique fingerprint.

Cite this