Intravitreal Delivery of Ganciclovir in Rabbits by Transscleral Iontophoresis

Tim T. Lam; ju fu; Ralph Chu; Kris Stojack; Edward Siew; Mark O.m. Tso

doi:10.1089/jop.1994.10.571

Intravitreal Delivery of Ganciclovir in Rabbits by Transscleral Iontophoresis

Tim T. Lam, ju fu, Ralph Chu, Kris Stojack, Edward Siew, Mark O.m. Tso

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

To avoid the side effects of systemic administration of ganciclovir (GCV) for the treatment of cytomegalovirus (CMV) retinitis, we studied transscleral iontophoresis of GCV into rabbit eyes. After a single application with 20% (w/w) aqueous solution of GCV at 1.0 mA for 15 min gave a vitreal/retinal level of GCV at 74±17 ug/ml at 2 hours as determined by HPLC. At 24 hours after iontophoresis the vitreal/retinal level was above therapeutic level at 4.2±0.6 ug/ml. At 72 hours, there was still detectable level in the vitreous/retina. Hence, transscleral iontophoresis is able to deliver effective dose of GCV into the vitreous. Multiple applications of iontophoresis should be examined as a possible means of CMV treatment.

Original language	English (US)
Pages (from-to)	571-575
Number of pages	5
Journal	Journal of Ocular Pharmacology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1089/jop.1994.10.571
State	Published - 1994
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology
Pharmacology
Pharmacology (medical)

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abstract = "To avoid the side effects of systemic administration of ganciclovir (GCV) for the treatment of cytomegalovirus (CMV) retinitis, we studied transscleral iontophoresis of GCV into rabbit eyes. After a single application with 20% (w/w) aqueous solution of GCV at 1.0 mA for 15 min gave a vitreal/retinal level of GCV at 74±17 ug/ml at 2 hours as determined by HPLC. At 24 hours after iontophoresis the vitreal/retinal level was above therapeutic level at 4.2±0.6 ug/ml. At 72 hours, there was still detectable level in the vitreous/retina. Hence, transscleral iontophoresis is able to deliver effective dose of GCV into the vitreous. Multiple applications of iontophoresis should be examined as a possible means of CMV treatment.",

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AU - Lam, Tim T.

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AU - Chu, Ralph

AU - Stojack, Kris

AU - Siew, Edward

AU - Tso, Mark O.m.

PY - 1994

Y1 - 1994

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Intravitreal Delivery of Ganciclovir in Rabbits by Transscleral Iontophoresis

Abstract

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