INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS for EXUDATIVE RETINAL ARTERIAL MACROANEURYSMS

Ahmad M. Mansour, Robert E. Foster, Roberto Gallego-Pinazo, Marilita M. Moschos, Robert A. Sisk, Jay Chhablani, Duangnate Rojanaporn, Tharikarn Sujirakul, J. Fernando Arevalo, Luiz H. Lima, Lihteh Wu, Abdulrazzak Charbaji, Ali O. Saatci, Hana A. Mansour, Clara Martinez-Rubio, Yogin Patel, Sankeert Gangakhedkar

Research output: Contribution to journalArticle

Abstract

Purpose:There is no established therapy for exudative-hemorrhagic complications in primary retinal arteriolar macroaneurysm (RAM).Methods:Retrospective multicenter interventional study of anti-vascular endothelial growth factor in symptomatic RAMs. Central macular thickness in m and best-corrected visual acuity in logMar were correlated with the RAM size and distance to the macula. Statistical analyses were performed using paired comparisons and Pearson correlation.Results:Thirty-two eyes (32 patients) were treated with a mean of 2.7 injections over a mean follow-up of 16.6 months. Initial best-corrected visual acuity correlated with the RAM size and distance to the macula (P = 0.02). Central macular thickness decreased by 131,180, and 211 m at 1, 2, and 3 months after the first injection (P < 0.001). Best-corrected visual acuity improved by 0.47 and 0.38 Early Treatment Diabetic Retinopathy Study lines at 2 and 3 months (P = 0.005). Anti-vascular endothelial growth factor response correlated with the RAM size (P = 0.04) and the distance to the macula (P = 0.009).Conclusion:Symptomatic RAMs can be treated successfully with anti-vascular endothelial growth factor injections, leading to a decrease in macular edema.

Original languageEnglish (US)
Pages (from-to)1133-1141
Number of pages9
JournalRetina
Volume39
Issue number6
DOIs
StatePublished - Jun 1 2019

Keywords

  • aflibercept
  • anti-vascular endothelial growth factor
  • bevacizumab
  • macular edema
  • optical coherence tomography
  • optical coherence tomography angiography
  • ranibizumab
  • retinal macroaneurysm

ASJC Scopus subject areas

  • Ophthalmology

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    Mansour, A. M., Foster, R. E., Gallego-Pinazo, R., Moschos, M. M., Sisk, R. A., Chhablani, J., Rojanaporn, D., Sujirakul, T., Arevalo, J. F., Lima, L. H., Wu, L., Charbaji, A., Saatci, A. O., Mansour, H. A., Martinez-Rubio, C., Patel, Y., & Gangakhedkar, S. (2019). INTRAVITREAL ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INJECTIONS for EXUDATIVE RETINAL ARTERIAL MACROANEURYSMS. Retina, 39(6), 1133-1141. https://doi.org/10.1097/IAE.0000000000002131