Intraventricular Glioblastomas

Atef Ben Nsir, Yassine Gdoura, Quoc-Anh Thai, Alia Zhani Kassar, Nejib Hattab, Hafedh Jemel

Research output: Contribution to journalArticle

Abstract

Background and Importance Although glioblastoma is the most common primary brain tumor, primary intraventricular locations are extremely rare; only 21 cases have been reported to date. Methods A retrospectively acquired database of all intracranial glioblastomas treated in 2 different neurosurgical departments during the last 10 years was queried. Patients with histologically proven intraventricular glioblastomas were included in the study. Results Eight patients were identified as having a histologically confirmed intraventricular glioblastoma. Patient age at diagnosis ranged from 6 to 74 years (mean 29.6 years) and the male/female ratio was 5:3. Increased intracranial pressure due to hydrocephalus was the main cause of the clinical manifestations. The tumor was located within the lateral ventricle in 6 cases and the anterior third ventricle in 2 others. Gross total tumor excision was achieved in 3 patients, whereas the surgical resection was subtotal in 4 cases and a surgical biopsy was performed in 1 patient. Postoperative adjuvant therapies were administered in 5 patients. Median survival time was 32.1 months, and 3 patients were alive at the end of study. All of them had isocitrate dehydrogenase-mutated tumors. Conclusions Intraventricular glioblastoma is extremely rare and can affect younger individuals including children. This malignant tumor should be included in the differential diagnosis of intraventricular lesions, especially in the lateral ventricles. Radical surgical resection can be associated with remarkable disease-free survival, especially in isocitrate dehydrogenase-mutated tumors. Because recurrence virtually is unavoidable, long-term follow-up is mandatory.

Original languageEnglish (US)
Pages (from-to)126-131
Number of pages6
JournalWorld Neurosurgery
Volume88
DOIs
StatePublished - Apr 1 2016

Fingerprint

Glioblastoma
Isocitrate Dehydrogenase
Lateral Ventricles
Neoplasms
Third Ventricle
Intracranial Pressure
Hydrocephalus
Brain Neoplasms
Disease-Free Survival
Differential Diagnosis
Databases
Biopsy
Recurrence
Survival

Keywords

  • Glioblastoma
  • Intraventricular tumors
  • Key words Chemotherapy
  • Radiotherapy
  • Transcallosal approach
  • Transcortical approach

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Ben Nsir, A., Gdoura, Y., Thai, Q-A., Zhani Kassar, A., Hattab, N., & Jemel, H. (2016). Intraventricular Glioblastomas. World Neurosurgery, 88, 126-131. https://doi.org/10.1016/j.wneu.2015.12.079

Intraventricular Glioblastomas. / Ben Nsir, Atef; Gdoura, Yassine; Thai, Quoc-Anh; Zhani Kassar, Alia; Hattab, Nejib; Jemel, Hafedh.

In: World Neurosurgery, Vol. 88, 01.04.2016, p. 126-131.

Research output: Contribution to journalArticle

Ben Nsir, A, Gdoura, Y, Thai, Q-A, Zhani Kassar, A, Hattab, N & Jemel, H 2016, 'Intraventricular Glioblastomas', World Neurosurgery, vol. 88, pp. 126-131. https://doi.org/10.1016/j.wneu.2015.12.079
Ben Nsir A, Gdoura Y, Thai Q-A, Zhani Kassar A, Hattab N, Jemel H. Intraventricular Glioblastomas. World Neurosurgery. 2016 Apr 1;88:126-131. https://doi.org/10.1016/j.wneu.2015.12.079
Ben Nsir, Atef ; Gdoura, Yassine ; Thai, Quoc-Anh ; Zhani Kassar, Alia ; Hattab, Nejib ; Jemel, Hafedh. / Intraventricular Glioblastomas. In: World Neurosurgery. 2016 ; Vol. 88. pp. 126-131.
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