TY - JOUR
T1 - Intravenous naloxone administration in schizophrenia and affective illness
AU - Davis, Glenn C.
AU - Bunney, William E.
AU - Defraites, Emanuel G.
AU - Kleinman, Joel E.
AU - Van Kammen, Daniel P.
AU - Post, Robert M.
AU - Wyatt, Richard J.
PY - 1977/1/1
Y1 - 1977/1/1
N2 - Fourteen schizophrenic patients and five patients with affective disorders were given naloxone (0.4 to 10 milligrams) or placebo intravenously in a double-blind fashion. Physicians' ratings of hallucinations, mannerisms and posturing, conceptual disorganization, psychosis, and mood did not change significantly. A single item, unusual thought content, improved significantly on the naloxone day compared to the placebo day. There was no improvement in mood in affectively ill patients rated either by themselves or by physicians. Naloxone did not markedly improve any patient studied, which suggests that the acute blockade of opiate receptors is not associated with global improvement in psychotic symptomatology.
AB - Fourteen schizophrenic patients and five patients with affective disorders were given naloxone (0.4 to 10 milligrams) or placebo intravenously in a double-blind fashion. Physicians' ratings of hallucinations, mannerisms and posturing, conceptual disorganization, psychosis, and mood did not change significantly. A single item, unusual thought content, improved significantly on the naloxone day compared to the placebo day. There was no improvement in mood in affectively ill patients rated either by themselves or by physicians. Naloxone did not markedly improve any patient studied, which suggests that the acute blockade of opiate receptors is not associated with global improvement in psychotic symptomatology.
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U2 - 10.1126/science.325650
DO - 10.1126/science.325650
M3 - Article
C2 - 325650
AN - SCOPUS:0017750260
SN - 0036-8075
VL - 197
SP - 74
EP - 77
JO - Science
JF - Science
IS - 4298
ER -