TY - JOUR
T1 - Intravenous meperidine during labor
T2 - A randomized comparison between nursing and patient-controlled administration
AU - Rayburn, William
AU - Leuschen, M. Patricia
AU - Earl, Robert
AU - Woods, Michael
AU - Lorkovic, Margaret
AU - Gaston-Johansson, Fannie
PY - 1989/11
Y1 - 1989/11
N2 - Preliminary reports about patient-controlled analgesia during labor have been promising. The purpose of this investigation was to compare our experience with meperidine given intravenously by the patient versus by a nurse. Sixtyfour healthy women beginning active labor (cervical dilation 3 cm) at term were randomly assigned to either self administer a 10-mg dose as often as every 20 minutes or have a nurse administer 25-50 mg every 3 hours as requested. The total meperidine dose and consumption rates were greater when administered by the patient than by a nurse. Maternal side effects occurred with similar frequency in both groups, and pain relief was judged to be equivalent. Maternal and umbilical serum concentrations of meperidine at delivery increased in the patient-controlled group if active labor lasted longer than 2 hours. Neonatal naloxone therapy was used more often when meperidine was administered by the patient than by a nurse (five of 31,16%, versus three of 33, 10%, respectively). Self-administration of intravenous meperidine by the laboring patient was not found to be advantageous over nursing administration, and may pose an increased threat to the infant.
AB - Preliminary reports about patient-controlled analgesia during labor have been promising. The purpose of this investigation was to compare our experience with meperidine given intravenously by the patient versus by a nurse. Sixtyfour healthy women beginning active labor (cervical dilation 3 cm) at term were randomly assigned to either self administer a 10-mg dose as often as every 20 minutes or have a nurse administer 25-50 mg every 3 hours as requested. The total meperidine dose and consumption rates were greater when administered by the patient than by a nurse. Maternal side effects occurred with similar frequency in both groups, and pain relief was judged to be equivalent. Maternal and umbilical serum concentrations of meperidine at delivery increased in the patient-controlled group if active labor lasted longer than 2 hours. Neonatal naloxone therapy was used more often when meperidine was administered by the patient than by a nurse (five of 31,16%, versus three of 33, 10%, respectively). Self-administration of intravenous meperidine by the laboring patient was not found to be advantageous over nursing administration, and may pose an increased threat to the infant.
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M3 - Article
C2 - 2682412
AN - SCOPUS:0024447785
SN - 0029-7844
VL - 74
SP - 702
EP - 706
JO - Obstetrics and gynecology
JF - Obstetrics and gynecology
IS - 5
ER -