TY - JOUR
T1 - Intravenous lidocaine and oral mexiletine block reflex bronchoconstriction in asthmatic subjects
AU - Groeben, Harald
AU - Foster, W. M.
AU - Brown, Robert H.
PY - 1996
Y1 - 1996
N2 - Stimulation of the airways of asthmatic individuals causes severe bronchoconstriction, which is in part neurally mediated via the vagus nerve. Local anesthetics are commonly administered to prevent this reflex-induced bronchoconstriction. Therefore, in a double-blind, placebo-controlled prospective study, we tested the effectiveness of oral mexiletine and intravenous lidocaine at blocking histamine-induced reflex bronchoconstriction. Fifteen subjects with mild asthma were selected (for whom the provocative concentration of histamine aerosol causing a 20% decrease in FEV1 (PC20) was less than 18 mg/ml). Subsequently, the subjects were pretreated with oral mexiletine, intravenous lidocaine, or placebo, and the histamine challenges were repeated. The baseline PC20 for histamine was 8.8 ± 1.8 mg/ml. Mexiletine and lidocaine at therapeutic serum concentrations blocked reflex bronchoconstriction. Oral mexiletine increased the PC20 to 21.1 ± 5.0 mg/ml (serum concentration: 0.7 ± 0.05 μg/ml). Likewise, intravenous lidocaine increased the PC20 to 24.5 ± 4.9 mg/ml (serum concentration: 2.6 ± 0.15 μg/ml). Oral mexiletine and intravenous lidocaine block reflex-induced bronchoconstriction. Furthermore, mexiletine may have additional airway benefits when selected for the treatment of dysrhythmias or chronic pain in patients with coexisting lung diseases.
AB - Stimulation of the airways of asthmatic individuals causes severe bronchoconstriction, which is in part neurally mediated via the vagus nerve. Local anesthetics are commonly administered to prevent this reflex-induced bronchoconstriction. Therefore, in a double-blind, placebo-controlled prospective study, we tested the effectiveness of oral mexiletine and intravenous lidocaine at blocking histamine-induced reflex bronchoconstriction. Fifteen subjects with mild asthma were selected (for whom the provocative concentration of histamine aerosol causing a 20% decrease in FEV1 (PC20) was less than 18 mg/ml). Subsequently, the subjects were pretreated with oral mexiletine, intravenous lidocaine, or placebo, and the histamine challenges were repeated. The baseline PC20 for histamine was 8.8 ± 1.8 mg/ml. Mexiletine and lidocaine at therapeutic serum concentrations blocked reflex bronchoconstriction. Oral mexiletine increased the PC20 to 21.1 ± 5.0 mg/ml (serum concentration: 0.7 ± 0.05 μg/ml). Likewise, intravenous lidocaine increased the PC20 to 24.5 ± 4.9 mg/ml (serum concentration: 2.6 ± 0.15 μg/ml). Oral mexiletine and intravenous lidocaine block reflex-induced bronchoconstriction. Furthermore, mexiletine may have additional airway benefits when selected for the treatment of dysrhythmias or chronic pain in patients with coexisting lung diseases.
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U2 - 10.1164/ajrccm.154.4.8887580
DO - 10.1164/ajrccm.154.4.8887580
M3 - Article
C2 - 8887580
AN - SCOPUS:0029858859
SN - 1073-449X
VL - 154
SP - 885
EP - 888
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 4 I
ER -