Intravenous injection of talc-containing drugs intended for oral use. A cause of pulmonary granulomatosis and pulmonary hypertension

Ernest N. Arnett, William E. Battle, John V. Russo, William C. Roberts

Research output: Contribution to journalArticlepeer-review

Abstract

Clinical and morphologic features are described in two patients known to have repeatedly injected intravenously talc-containing drugs intended for oral use. In one patient severe pulmonary hypertension developed; the talc granulomas in him were located predominantly within the pulmonary arteries. The second patient had normal pulmonary arterial pressures, and the talc granulomas in him were located predominantly in the pulmonary interstitium. Of 19 previously described patients with pulmonary talc granulomes, 12 had morphologic evidence of pulmonary hypertension (in three of severe degree); in each, talc granulomes were located predominantly within the pulmonary arteries. In those without signs of pulmonary hypertension, granulomas were located predominantly in the pulmonary interstitium. Why there are differences in the distribution of the talc granulomas is unclear. It is clear, however, as demonstrated by one of our patients, that severe pulmonary hypertension may be a consequence of intravenous injection of drugs intended for oral use.

Original languageEnglish (US)
Pages (from-to)711-718
Number of pages8
JournalThe American journal of medicine
Volume60
Issue number5
DOIs
StatePublished - May 10 1976

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Intravenous injection of talc-containing drugs intended for oral use. A cause of pulmonary granulomatosis and pulmonary hypertension'. Together they form a unique fingerprint.

Cite this