Intravascular malignant cell dissemination pattern in KRAS mutant advanced lung adenocarcinoma: Autopsy findings

Lina S Correa Cerro, Fausto J Rodriguez, Erika Rodriguez

Research output: Contribution to journalArticle

Abstract

Lung cancer is the most common cause of cancer-related death in the United States. Adenocarcinoma is the most common primary malignancy of the lung. Approximately 50-80% of pulmonary adenocarcinomas have a known oncogenic driver mutation, KRAS mutation being the most common. In the current study, we report the autopsy findings of two patients with advanced stage lung adenocarcinoma presenting with massive intravascular dissemination. Both cases showed a predominantly solid pattern as well as a KRAS mutation. The clinicopathologic implications are discussed.

Original languageEnglish (US)
Pages (from-to)8456-8463
Number of pages8
JournalInternational Journal of Clinical and Experimental Pathology
Volume9
Issue number8
StatePublished - 2016

Keywords

  • Adenocarcinoma
  • Brain metastasis
  • Disseminated intravascular tumor
  • KRAS mutation
  • Non-small cell lung cancer
  • Pulmonary tumor microembolism

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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