TY - JOUR
T1 - Intravascular catheter exchange and duration of candidemia
AU - NIAID Mycoses Study Group
AU - Candidemia Study Group
AU - NIAID Mycoses Study Group
AU - Candidemia Study Group
AU - NIAID Mycoses Study Group
AU - Candidemia Study Group
AU - NIAID Mycoses Study Group
AU - Candidemia Study Group
AU - NIAID Mycoses Study Group
AU - Candidemia Study Group
AU - NIAID Mycoses Study Group
AU - Candidemia Study Group
AU - NIAID Mycoses Study Group
AU - Candidemia Study Group
AU - Rex, John H.
AU - Bennett, John E.
AU - Sugar, Alan M.
AU - Pappas, Peter G.
AU - Serody, Jonathan
AU - Edwards, John E.
AU - Washburn, Ronald G.
N1 - Funding Information:
Received 19 September 1994; revised 6 February 1995. This work was presented in part at the 12th Congress of the International Society for Human and Animal Mycology held on 13-18 March 1994 in Adelaide, Australia. Informed consent was obtained from all patients or their families and the study was reviewed and approved by the Institution Review Board of each author's institution. Grant support: This work was supported in part by grants from Roerig/Pfizer and in part by the Mycoses Study Group of the National Institute of Allergy and Infectious Diseases (N01-AI-15082). Reprints or correspondence: Dr. John H. Rex, University of Texas Medical School at Houston, 6431 Fannin 1728 JFB, Houston, Texas 77030.
PY - 1995/10
Y1 - 1995/10
N2 - During a comparative trial of amphotericin B vs. fluconazole for treatment of candidemia in nonneutropenic patients, data on the management of intravascular catheters were collected. Complete records were available for 91% of the 206 study patients. For the subset of patients with a catheter in place at the time of their first positive blood culture, removal and replacement of all intravascular catheters without exchange over a guidewire from a preexisting line on or before the first day the study drug was administered were associated with a reduction in the subsequent mean duration (±SE) of candidemia, from 5.6 ± 0.8 days to 2.6 ± 0.5 days (>P <.001).
AB - During a comparative trial of amphotericin B vs. fluconazole for treatment of candidemia in nonneutropenic patients, data on the management of intravascular catheters were collected. Complete records were available for 91% of the 206 study patients. For the subset of patients with a catheter in place at the time of their first positive blood culture, removal and replacement of all intravascular catheters without exchange over a guidewire from a preexisting line on or before the first day the study drug was administered were associated with a reduction in the subsequent mean duration (±SE) of candidemia, from 5.6 ± 0.8 days to 2.6 ± 0.5 days (>P <.001).
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U2 - 10.1093/clinids/21.4.994
DO - 10.1093/clinids/21.4.994
M3 - Article
C2 - 8645855
AN - SCOPUS:0028865579
VL - 21
SP - 994
EP - 996
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 4
ER -