Intravascular bronchiolo-alveolar tumor (IVBAT). A low-grade sclerosing epithelioid angiosarcoma of lung

Belur Bhagavan, H. D. Dorfman, M. S N Murthy, J. C. Eggleston

Research output: Contribution to journalArticle

Abstract

Intravascular bronchiolo-alveolar tumor (IVBAT) is a rare and highly distinctive pulmonary tumor of disputed cellular nature. Both epithelial and endothelial differentiation of this neoplasm have been suggested. We have studied multiple nodules of IVBATs from three patients by light and electron microscopy and by immunohistochemical methods for Factor VIII-related antigen (FVIII RAG). Our light and ultrastructural studies are in essential agreement with the previous suggestion of the endothelial nature of the neoplasm and our demonstration of the presence of FVIII RAG in many of the tumor cells offers new evidence strongly supportive of their endothelial differentiation. We believe that IVBAT and a group of extrapulmonary tumors described as epithelioid hemangioendothelioma and endovascular papillary angioendothelioma are similar biologically indolent neoplasms of epithelioid and dendritic endothelial cells characterized by stromal sclerosis, intravascular spread, a low incidence of metastases and slow clinical evolution. Thus, we regard IVBAT as a low-grade sclerosing angiosarcoma of the lung.

Original languageEnglish (US)
Pages (from-to)41-52
Number of pages12
JournalAmerican Journal of Surgical Pathology
Volume6
Issue number1
StatePublished - 1982

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Hemangiosarcoma
Lung
Neoplasms
von Willebrand Factor
Epithelioid Hemangioendothelioma
Hemangioendothelioma
Light
Sclerosis
Dendritic Cells
Electron Microscopy
Endothelial Cells
Neoplasm Metastasis
Incidence

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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Intravascular bronchiolo-alveolar tumor (IVBAT). A low-grade sclerosing epithelioid angiosarcoma of lung. / Bhagavan, Belur; Dorfman, H. D.; Murthy, M. S N; Eggleston, J. C.

In: American Journal of Surgical Pathology, Vol. 6, No. 1, 1982, p. 41-52.

Research output: Contribution to journalArticle

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AB - Intravascular bronchiolo-alveolar tumor (IVBAT) is a rare and highly distinctive pulmonary tumor of disputed cellular nature. Both epithelial and endothelial differentiation of this neoplasm have been suggested. We have studied multiple nodules of IVBATs from three patients by light and electron microscopy and by immunohistochemical methods for Factor VIII-related antigen (FVIII RAG). Our light and ultrastructural studies are in essential agreement with the previous suggestion of the endothelial nature of the neoplasm and our demonstration of the presence of FVIII RAG in many of the tumor cells offers new evidence strongly supportive of their endothelial differentiation. We believe that IVBAT and a group of extrapulmonary tumors described as epithelioid hemangioendothelioma and endovascular papillary angioendothelioma are similar biologically indolent neoplasms of epithelioid and dendritic endothelial cells characterized by stromal sclerosis, intravascular spread, a low incidence of metastases and slow clinical evolution. Thus, we regard IVBAT as a low-grade sclerosing angiosarcoma of the lung.

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