Intratumoral microdistribution of [131I]MB-1 in patients with B-cell lymphoma following radioimmunotherapy

Raya S. Brown, Mark S. Kaminski, Susan J. Fisher, Alfred E. Chang, Richard L. Wahl

Research output: Contribution to journalArticlepeer-review

Abstract

Intratumoral microdistribution of radiolabeled anti-CD37 murine monoclonal antibody, [131I]MB-1, in lymph nodes from five patients with non-Hodgkin's B-cell lymphoma following radioimmunotherapy were evaluated by microautoradiography and image analysis of macroautoradiographs. Microdistribution of radioactivity was highly heterogeneous: silver grain counts varied from 28-70 to 8-10 per 400X field, and the coefficients of variations calculated by image analysis ranged between 42.5 and 79.3%. Variable radiation doses delivered could have contributed to the limited durability of tumor regression.

Original languageEnglish (US)
Pages (from-to)657-663
Number of pages7
JournalNuclear Medicine and Biology
Volume24
Issue number7
DOIs
StatePublished - Oct 1 1997

Keywords

  • Autoradiography
  • Human
  • Lymphoma
  • Monoclonal antibodies
  • Pan-B cell
  • Radioimmunotherapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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