Abstract
Failure to achieve complete remission after radiation therapy is a predictor of patient mortality, and hypoxic cancer cells are more likely to survive radiation therapy. Recent studies have shown that radiation-induced endothelial cell death results in secondary tumor cell killing. In this issue of Cancer Cell, Moeller et al. (2004) now provide evidence that radiation induces HIF-1-mediated expression of VEGF and bFGF in tumor cells, which promotes endothelial cell survival.
Original language | English (US) |
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Pages (from-to) | 405-406 |
Number of pages | 2 |
Journal | Cancer cell |
Volume | 5 |
Issue number | 5 |
DOIs | |
State | Published - May 2004 |
ASJC Scopus subject areas
- Oncology
- Cell Biology
- Cancer Research