Intratumoral chemotherapy.

K. A. Walter, Rafael J Tamargo, Alessandro Olivi, P. C. Burger, Henry Brem

Research output: Contribution to journalArticle

Abstract

In an effort to improve survival from malignant gliomas, investigators have used intratumoral chemotherapy protocols to deliver high doses of tumoricidal agents directly to the brain. Theoretically, these infusions bypass the blood-brain barrier, minimize systemic drug levels and the side effects of chemotherapy, and achieve prolonged elevations of intracerebral chemotherapeutic agents relative to those obtainable by systemic administration. Almost all major classes of chemotherapeutic agents have been examined as possible intratumoral therapies via delivery approaches ranging from simple intratumoral injections to implantable computer-driven constant infusion pumps and biodegradable polymer matrices. In this review, we summarize the major clinical trials and experimental investigations underlying the development of intratumoral chemotherapy as a treatment for gliomas.

Original languageEnglish (US)
Pages (from-to)1128-1145
Number of pages18
JournalNeurosurgery
Volume37
Issue number6
StatePublished - Dec 1995

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Drug Therapy
Glioma
Infusion Pumps
Drug-Related Side Effects and Adverse Reactions
Blood-Brain Barrier
Polymers
Research Personnel
Clinical Trials
Injections
Brain
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Walter, K. A., Tamargo, R. J., Olivi, A., Burger, P. C., & Brem, H. (1995). Intratumoral chemotherapy. Neurosurgery, 37(6), 1128-1145.

Intratumoral chemotherapy. / Walter, K. A.; Tamargo, Rafael J; Olivi, Alessandro; Burger, P. C.; Brem, Henry.

In: Neurosurgery, Vol. 37, No. 6, 12.1995, p. 1128-1145.

Research output: Contribution to journalArticle

Walter, KA, Tamargo, RJ, Olivi, A, Burger, PC & Brem, H 1995, 'Intratumoral chemotherapy.', Neurosurgery, vol. 37, no. 6, pp. 1128-1145.
Walter KA, Tamargo RJ, Olivi A, Burger PC, Brem H. Intratumoral chemotherapy. Neurosurgery. 1995 Dec;37(6):1128-1145.
Walter, K. A. ; Tamargo, Rafael J ; Olivi, Alessandro ; Burger, P. C. ; Brem, Henry. / Intratumoral chemotherapy. In: Neurosurgery. 1995 ; Vol. 37, No. 6. pp. 1128-1145.
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