Intrathyroidal parathyroid glands: Small, but mighty (a Napoleon phenomenon)

Haggi Mazeh, Guennadi Kouniavsky, David F. Schneider, Konstantinos I. Makris, Rebecca S. Sippel, Alan P B Dackiw, Herbert Chen, Martha A. Zeiger

Research output: Contribution to journalArticle

Abstract

Background: Intrathyroidal parathyroid adenomas (ITPAs) are a rare entity. The aim of this study is to describe the experience of 2 endocrine surgery centers and to distinguish characteristics of intrathyroidal parathyroid adenoma and nonintrathyroidal parathyroid adenomas. Methods: We included patients who had undergone operations for primary hyperparathyroidism who had intrathyroidal parathyroid adenomas. Patients with single intrathyroidal parathyroid adenomas were also compared to age- and sex-matched controls with nonintrathyroidal parathyroid adenomas. Results: Of 4,868 patients who underwent parathyroidectomy between January 2002 and June 2011, we identified 53 (1%) patients with intrathyroidal parathyroid adenoma. Sestamibi and ultrasound scans correctly identified the adenoma in 35 (70%) and 11 (61%) cases, respectively. Single adenomas were identified in 44 (83%) patients, double adenomas in 4 (8%) patients, and hyperplasia in 5 (9%) patients. Lobectomy was performed in 17 (32%) patients; enucleation was used in 36 (68%) patients. Cure was achieved in all patients and no patients experienced a recurrence. Patients with single intrathyroidal parathyroid adenomas had significantly smaller glands than patients with nonintrathyroidal parathyroid adenomas (325 ± 47 vs 772 ± 61 mg; P

Original languageEnglish (US)
Pages (from-to)1193-1200
Number of pages8
JournalSurgery
Volume152
Issue number6
DOIs
StatePublished - Dec 2012

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Parathyroid Glands
Parathyroid Neoplasms
Adenoma
Parathyroidectomy
Primary Hyperparathyroidism
Hyperplasia

ASJC Scopus subject areas

  • Surgery

Cite this

Mazeh, H., Kouniavsky, G., Schneider, D. F., Makris, K. I., Sippel, R. S., Dackiw, A. P. B., ... Zeiger, M. A. (2012). Intrathyroidal parathyroid glands: Small, but mighty (a Napoleon phenomenon). Surgery, 152(6), 1193-1200. https://doi.org/10.1016/j.surg.2012.08.026

Intrathyroidal parathyroid glands : Small, but mighty (a Napoleon phenomenon). / Mazeh, Haggi; Kouniavsky, Guennadi; Schneider, David F.; Makris, Konstantinos I.; Sippel, Rebecca S.; Dackiw, Alan P B; Chen, Herbert; Zeiger, Martha A.

In: Surgery, Vol. 152, No. 6, 12.2012, p. 1193-1200.

Research output: Contribution to journalArticle

Mazeh, H, Kouniavsky, G, Schneider, DF, Makris, KI, Sippel, RS, Dackiw, APB, Chen, H & Zeiger, MA 2012, 'Intrathyroidal parathyroid glands: Small, but mighty (a Napoleon phenomenon)', Surgery, vol. 152, no. 6, pp. 1193-1200. https://doi.org/10.1016/j.surg.2012.08.026
Mazeh H, Kouniavsky G, Schneider DF, Makris KI, Sippel RS, Dackiw APB et al. Intrathyroidal parathyroid glands: Small, but mighty (a Napoleon phenomenon). Surgery. 2012 Dec;152(6):1193-1200. https://doi.org/10.1016/j.surg.2012.08.026
Mazeh, Haggi ; Kouniavsky, Guennadi ; Schneider, David F. ; Makris, Konstantinos I. ; Sippel, Rebecca S. ; Dackiw, Alan P B ; Chen, Herbert ; Zeiger, Martha A. / Intrathyroidal parathyroid glands : Small, but mighty (a Napoleon phenomenon). In: Surgery. 2012 ; Vol. 152, No. 6. pp. 1193-1200.
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