Intrathecal synthesis of anti-HIV IgG: Correlation with increasing duration of HIV-1 infection

G. Van Wielink, J. C. McArthur, T. Moench, H. Farzadegan, J. H. McArthur, R. T. Johnson, A. Saah

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Abstract

We determined intrathecal synthesis (ITS) of anti-HIV-1 immunoglobulin in 62 CSF samples from 51 HIV-1 seropositive homosexual men using an ELISA technique with paired serum and CSF samples diluted to a concentration of IgG of 10 pg/ml. All subjects were neurologically normal and none was taking zidovudine. We estimated duration of HIV-1 infection from semiannual serologic testing during the 3-year period before CSF analysis and detected ITS of anti-HIV-1 immunoglobulin in 2 of 12 (17%) of those with < 18 months of HIV-1 seropositivity, in 3 of 21 (14%) with 19 to 36 months, and in 13 of29 (45%) with > 36 months of HIV-1 seropositivity (p = 0.037). There was a trend toward an inverse relationship between level of ITS and the peripheral blood T-helper lymphocyte count. This study demonstrates that increasing ITS of anti-HIV-1 IgG is related to duration of HIV-1 infection and suggests an inverse correlation with systemic immune status. The detection of ITS of anti-HIV-1 immunoglobulin is not necessarily a marker of clinically overt neurologic involvement.

Original languageEnglish (US)
Pages (from-to)816-819
Number of pages4
JournalNeurology
Volume40
Issue number5
StatePublished - May 1990

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ASJC Scopus subject areas

  • Clinical Neurology

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