Intrathecal synthesis of anti-HIV IgG

Correlation with increasing duration of HIV-1 infection

G. Van Wielink, Justin Charles McArthur, T. Moench, Homayoon Farzadegan, J. H. McArthur, Richard Johnson, A. Saah

Research output: Contribution to journalArticle

Abstract

We determined intrathecal synthesis (ITS) of anti-HIV-1 immunoglobulin in 62 CSF samples from 51 HIV-1 seropositive homosexual men using an ELISA technique with paired serum and CSF samples diluted to a concentration of IgG of 10 pg/ml. All subjects were neurologically normal and none was taking zidovudine. We estimated duration of HIV-1 infection from semiannual serologic testing during the 3-year period before CSF analysis and detected ITS of anti-HIV-1 immunoglobulin in 2 of 12 (17%) of those with <18 months of HIV-1 seropositivity, in 3 of 21 (14%) with 19 to 36 months, and in 13 of29 (45%) with > 36 months of HIV-1 seropositivity (p = 0.037). There was a trend toward an inverse relationship between level of ITS and the peripheral blood T-helper lymphocyte count. This study demonstrates that increasing ITS of anti-HIV-1 IgG is related to duration of HIV-1 infection and suggests an inverse correlation with systemic immune status. The detection of ITS of anti-HIV-1 immunoglobulin is not necessarily a marker of clinically overt neurologic involvement.

Original languageEnglish (US)
Pages (from-to)816-819
Number of pages4
JournalNeurology
Volume40
Issue number5
StatePublished - 1990

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HIV Infections
HIV-1
HIV
Immunoglobulins
Immunoglobulin G
HIV Seropositivity
anti-IgG
AIDS/HIV
Infection
Zidovudine
Lymphocyte Count
Nervous System
Enzyme-Linked Immunosorbent Assay
Serum

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Intrathecal synthesis of anti-HIV IgG : Correlation with increasing duration of HIV-1 infection. / Van Wielink, G.; McArthur, Justin Charles; Moench, T.; Farzadegan, Homayoon; McArthur, J. H.; Johnson, Richard; Saah, A.

In: Neurology, Vol. 40, No. 5, 1990, p. 816-819.

Research output: Contribution to journalArticle

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abstract = "We determined intrathecal synthesis (ITS) of anti-HIV-1 immunoglobulin in 62 CSF samples from 51 HIV-1 seropositive homosexual men using an ELISA technique with paired serum and CSF samples diluted to a concentration of IgG of 10 pg/ml. All subjects were neurologically normal and none was taking zidovudine. We estimated duration of HIV-1 infection from semiannual serologic testing during the 3-year period before CSF analysis and detected ITS of anti-HIV-1 immunoglobulin in 2 of 12 (17{\%}) of those with <18 months of HIV-1 seropositivity, in 3 of 21 (14{\%}) with 19 to 36 months, and in 13 of29 (45{\%}) with > 36 months of HIV-1 seropositivity (p = 0.037). There was a trend toward an inverse relationship between level of ITS and the peripheral blood T-helper lymphocyte count. This study demonstrates that increasing ITS of anti-HIV-1 IgG is related to duration of HIV-1 infection and suggests an inverse correlation with systemic immune status. The detection of ITS of anti-HIV-1 immunoglobulin is not necessarily a marker of clinically overt neurologic involvement.",
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AU - Johnson, Richard

AU - Saah, A.

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